Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters

Atif Ali Hashmi, Kashif Ali Hashmi, Muhammad Irfan, Saadia Mehmood Khan, Muhammad Muzzammil Edhi, Javaria Parwez Ali, Shumaila Kanwal Hashmi, Huda Asif, Naveen Faridi, Amir Khan

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Objectives: Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index. Cancer management should be according to loco-regional profile; therefore, we aimed to determine ki67 index in 1951 cases of intrinsic breast cancer subtypes and its association with other prognostic parameters in our set up. Results: Triple negative breast cancers showed highest ki67 index (mean 50.9 ± 23.7%) followed by Her2neu (mean 42.6 ± 21.6%) and luminal B cancers (mean 34.9 ± 20.05%). Metaplastic and medullary breast cancers significantly showed higher ki67 index as compared to ductal carcinoma, NOS. No significant association of ki67 index was noted with any of the histologic parameters in different subtypes of breast cancer expect for tumor grade. Although, ki67 index is a valuable biomarker in breast cancer, however no independent prognostic significance of ki67 could be established in our study.

Original languageEnglish
Article number605
JournalBMC Research Notes
Volume12
Issue number1
DOIs
Publication statusPublished - 23 Sept 2019
Externally publishedYes

Keywords

  • Breast cancer
  • ER
  • Her2neu
  • Intrinsic subtypes of breast cancer
  • Ki67 index
  • PR

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