Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

Rufus O. Akinyemi; Fred S. Sarfo; Joshua Akinyemi; Arti Singh; Matthew Onoja Akpa; Albert Akpalu; Lukman Owolabi; Abiodun M. Adeoye; Reginald Obiako; Kolawole Wahab; Emmanuel Sanya; Morenikeji Komolafe; Godwin Ogbole; Michael Fawale; Philip Adebayo; Godwin Osaigbovo; Taofiki Sunmonu; Paul Olowoyo; Innocent Chukwuonye; Yahaya Obiabo; Olaleye Adeniji; Gregory Fakunle; Ezinne Melikam; Raelle Saulson; Joseph Yaria; Kelechi Uwanruochi; Phillip Ibinaiye; Ganiyu Adeniyi Amusa; Isah Suleiman Yahaya; Abdullahi Hamisu Dambatta; Mercy Faniyan; Peter Olowoniyi; Andrew Bock-Oruma; Odo Chidi Joseph; Ayodipupo Oguntade; Philip Kolo; Ruth Laryea; Sulaiman Lakoh; Ezinne Uvere; Temitope Farombi; Josephine Akpalu; Olalekan Oyinloye; Lambert Appiah; Benedict Calys-Tagoe; Vincent Shidali; Nasir Abdulkadir Tabari; Oladimeji Adebayo; Richard Efidi; Osi Adeleye; Dorcas Owusu; Luqman Ogunjimi; Olumayowa Aridegbe; Chidiebere Lucius Imoh; Taofeeq Sanni; Mulugeta Gebreziabher; Tiwari Hemant; Oyedunni Arulogun; Adesola Ogunniyi; Carolyn Jenkins; Mayowa Owolabi; Bruce Ovbiagele

doi:10.1177/1747493018790059

Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

Rufus O. Akinyemi, Fred S. Sarfo, Joshua Akinyemi, Arti Singh, Matthew Onoja Akpa, Albert Akpalu, Lukman Owolabi, Abiodun M. Adeoye, Reginald Obiako, Kolawole Wahab, Emmanuel Sanya, Morenikeji Komolafe, Godwin Ogbole, Michael Fawale, Philip Adebayo, Godwin Osaigbovo, Taofiki Sunmonu, Paul Olowoyo, Innocent Chukwuonye, Yahaya ObiaboOlaleye Adeniji, Gregory Fakunle, Ezinne Melikam, Raelle Saulson, Joseph Yaria, Kelechi Uwanruochi, Phillip Ibinaiye, Ganiyu Adeniyi Amusa, Isah Suleiman Yahaya, Abdullahi Hamisu Dambatta, Mercy Faniyan, Peter Olowoniyi, Andrew Bock-Oruma, Odo Chidi Joseph, Ayodipupo Oguntade, Philip Kolo, Ruth Laryea, Sulaiman Lakoh, Ezinne Uvere, Temitope Farombi, Josephine Akpalu, Olalekan Oyinloye, Lambert Appiah, Benedict Calys-Tagoe, Vincent Shidali, Nasir Abdulkadir Tabari, Oladimeji Adebayo, Richard Efidi, Osi Adeleye, Dorcas Owusu, Luqman Ogunjimi, Olumayowa Aridegbe, Chidiebere Lucius Imoh, Taofeeq Sanni, Mulugeta Gebreziabher, Tiwari Hemant, Oyedunni Arulogun, Adesola Ogunniyi, Carolyn Jenkins, Mayowa Owolabi, Bruce Ovbiagele

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Original language	English
Pages (from-to)	69-79
Number of pages	11
Journal	International Journal of Stroke
Volume	14
Issue number	1
DOIs	https://doi.org/10.1177/1747493018790059
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

African
Sub-Saharan Africa
chronic disease
developing countries
genetic disorders
stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1747493018790059

Cite this

Akinyemi, R. O., Sarfo, F. S., Akinyemi, J., Singh, A., Onoja Akpa, M., Akpalu, A., Owolabi, L., Adeoye, A. M., Obiako, R., Wahab, K., Sanya, E., Komolafe, M., Ogbole, G., Fawale, M., Adebayo, P., Osaigbovo, G., Sunmonu, T., Olowoyo, P., Chukwuonye, I., ... Ovbiagele, B. (2019). Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study. International Journal of Stroke, 14(1), 69-79. https://doi.org/10.1177/1747493018790059

@article{d38c2877642a42d7a94ce214dcf1fc5d,

title = "Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study",

abstract = "Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.",

keywords = "African, Sub-Saharan Africa, chronic disease, developing countries, genetic disorders, stroke",

author = "Akinyemi, {Rufus O.} and Sarfo, {Fred S.} and Joshua Akinyemi and Arti Singh and {Onoja Akpa}, Matthew and Albert Akpalu and Lukman Owolabi and Adeoye, {Abiodun M.} and Reginald Obiako and Kolawole Wahab and Emmanuel Sanya and Morenikeji Komolafe and Godwin Ogbole and Michael Fawale and Philip Adebayo and Godwin Osaigbovo and Taofiki Sunmonu and Paul Olowoyo and Innocent Chukwuonye and Yahaya Obiabo and Olaleye Adeniji and Gregory Fakunle and Ezinne Melikam and Raelle Saulson and Joseph Yaria and Kelechi Uwanruochi and Phillip Ibinaiye and Amusa, {Ganiyu Adeniyi} and Yahaya, {Isah Suleiman} and Dambatta, {Abdullahi Hamisu} and Mercy Faniyan and Peter Olowoniyi and Andrew Bock-Oruma and Joseph, {Odo Chidi} and Ayodipupo Oguntade and Philip Kolo and Ruth Laryea and Sulaiman Lakoh and Ezinne Uvere and Temitope Farombi and Josephine Akpalu and Olalekan Oyinloye and Lambert Appiah and Benedict Calys-Tagoe and Vincent Shidali and Tabari, {Nasir Abdulkadir} and Oladimeji Adebayo and Richard Efidi and Osi Adeleye and Dorcas Owusu and Luqman Ogunjimi and Olumayowa Aridegbe and Imoh, {Chidiebere Lucius} and Taofeeq Sanni and Mulugeta Gebreziabher and Tiwari Hemant and Oyedunni Arulogun and Adesola Ogunniyi and Carolyn Jenkins and Mayowa Owolabi and Bruce Ovbiagele",

note = "Publisher Copyright: {\textcopyright} 2018 World Stroke Organization.",

year = "2019",

month = jan,

day = "1",

doi = "10.1177/1747493018790059",

language = "English",

volume = "14",

pages = "69--79",

journal = "International Journal of Stroke",

issn = "1747-4930",

publisher = "SAGE Publications Ltd",

number = "1",

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Akinyemi, RO, Sarfo, FS, Akinyemi, J, Singh, A, Onoja Akpa, M, Akpalu, A, Owolabi, L, Adeoye, AM, Obiako, R, Wahab, K, Sanya, E, Komolafe, M, Ogbole, G, Fawale, M, Adebayo, P, Osaigbovo, G, Sunmonu, T, Olowoyo, P, Chukwuonye, I, Obiabo, Y, Adeniji, O, Fakunle, G, Melikam, E, Saulson, R, Yaria, J, Uwanruochi, K, Ibinaiye, P, Amusa, GA, Yahaya, IS, Dambatta, AH, Faniyan, M, Olowoniyi, P, Bock-Oruma, A, Joseph, OC, Oguntade, A, Kolo, P, Laryea, R, Lakoh, S, Uvere, E, Farombi, T, Akpalu, J, Oyinloye, O, Appiah, L, Calys-Tagoe, B, Shidali, V, Tabari, NA, Adebayo, O, Efidi, R, Adeleye, O, Owusu, D, Ogunjimi, L, Aridegbe, O, Imoh, CL, Sanni, T, Gebreziabher, M, Hemant, T, Arulogun, O, Ogunniyi, A, Jenkins, C, Owolabi, M & Ovbiagele, B 2019, 'Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study', International Journal of Stroke, vol. 14, no. 1, pp. 69-79. https://doi.org/10.1177/1747493018790059

TY - JOUR

T1 - Knowledge, attitudes and practices of West Africans on genetic studies of stroke

T2 - Evidence from the SIREN Study

AU - Akinyemi, Rufus O.

AU - Sarfo, Fred S.

AU - Akinyemi, Joshua

AU - Singh, Arti

AU - Onoja Akpa, Matthew

AU - Akpalu, Albert

AU - Owolabi, Lukman

AU - Adeoye, Abiodun M.

AU - Obiako, Reginald

AU - Wahab, Kolawole

AU - Sanya, Emmanuel

AU - Komolafe, Morenikeji

AU - Ogbole, Godwin

AU - Fawale, Michael

AU - Adebayo, Philip

AU - Osaigbovo, Godwin

AU - Sunmonu, Taofiki

AU - Olowoyo, Paul

AU - Chukwuonye, Innocent

AU - Obiabo, Yahaya

AU - Adeniji, Olaleye

AU - Fakunle, Gregory

AU - Melikam, Ezinne

AU - Saulson, Raelle

AU - Yaria, Joseph

AU - Uwanruochi, Kelechi

AU - Ibinaiye, Phillip

AU - Amusa, Ganiyu Adeniyi

AU - Yahaya, Isah Suleiman

AU - Dambatta, Abdullahi Hamisu

AU - Faniyan, Mercy

AU - Olowoniyi, Peter

AU - Bock-Oruma, Andrew

AU - Joseph, Odo Chidi

AU - Oguntade, Ayodipupo

AU - Kolo, Philip

AU - Laryea, Ruth

AU - Lakoh, Sulaiman

AU - Uvere, Ezinne

AU - Farombi, Temitope

AU - Akpalu, Josephine

AU - Oyinloye, Olalekan

AU - Appiah, Lambert

AU - Calys-Tagoe, Benedict

AU - Shidali, Vincent

AU - Tabari, Nasir Abdulkadir

AU - Adebayo, Oladimeji

AU - Efidi, Richard

AU - Adeleye, Osi

AU - Owusu, Dorcas

AU - Ogunjimi, Luqman

AU - Aridegbe, Olumayowa

AU - Imoh, Chidiebere Lucius

AU - Sanni, Taofeeq

AU - Gebreziabher, Mulugeta

AU - Hemant, Tiwari

AU - Arulogun, Oyedunni

AU - Ogunniyi, Adesola

AU - Jenkins, Carolyn

AU - Owolabi, Mayowa

AU - Ovbiagele, Bruce

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

AB - Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

KW - African

KW - Sub-Saharan Africa

KW - chronic disease

KW - developing countries

KW - genetic disorders

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85050660594&partnerID=8YFLogxK

U2 - 10.1177/1747493018790059

DO - 10.1177/1747493018790059

M3 - Article

C2 - 30040054

AN - SCOPUS:85050660594

SN - 1747-4930

VL - 14

SP - 69

EP - 79

JO - International Journal of Stroke

JF - International Journal of Stroke

IS - 1

ER -

Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

Abstract

Keywords

UN SDGs

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