Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

Rufus O. Akinyemi, Fred S. Sarfo, Joshua Akinyemi, Arti Singh, Matthew Onoja Akpa, Albert Akpalu, Lukman Owolabi, Abiodun M. Adeoye, Reginald Obiako, Kolawole Wahab, Emmanuel Sanya, Morenikeji Komolafe, Godwin Ogbole, Michael Fawale, Philip Adebayo, Godwin Osaigbovo, Taofiki Sunmonu, Paul Olowoyo, Innocent Chukwuonye, Yahaya ObiaboOlaleye Adeniji, Gregory Fakunle, Ezinne Melikam, Raelle Saulson, Joseph Yaria, Kelechi Uwanruochi, Phillip Ibinaiye, Ganiyu Adeniyi Amusa, Isah Suleiman Yahaya, Abdullahi Hamisu Dambatta, Mercy Faniyan, Peter Olowoniyi, Andrew Bock-Oruma, Odo Chidi Joseph, Ayodipupo Oguntade, Philip Kolo, Ruth Laryea, Sulaiman Lakoh, Ezinne Uvere, Temitope Farombi, Josephine Akpalu, Olalekan Oyinloye, Lambert Appiah, Benedict Calys-Tagoe, Vincent Shidali, Nasir Abdulkadir Tabari, Oladimeji Adebayo, Richard Efidi, Osi Adeleye, Dorcas Owusu, Luqman Ogunjimi, Olumayowa Aridegbe, Chidiebere Lucius Imoh, Taofeeq Sanni, Mulugeta Gebreziabher, Tiwari Hemant, Oyedunni Arulogun, Adesola Ogunniyi, Carolyn Jenkins, Mayowa Owolabi, Bruce Ovbiagele

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Original languageEnglish
Pages (from-to)69-79
Number of pages11
JournalInternational Journal of Stroke
Volume14
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Keywords

  • African
  • Sub-Saharan Africa
  • chronic disease
  • developing countries
  • genetic disorders
  • stroke

Fingerprint

Dive into the research topics of 'Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study'. Together they form a unique fingerprint.

Cite this