Large mediastinal mass in a 15-year-old boy

Mariyam Gohar Ali, Ali Bin Sarwar Zubairi, Farah Naz Qamar

Research output: Contribution to journalArticlepeer-review


Hyperimmunoglobulin E syndrome is a rare multisystem inherited disorder characterised by high serum IgE levels, skin disorder causing eczema, dermatitis, recurrent staphylococcal infections and pulmonary infections and various skeletal and connective tissue abnormalities. Common presentation is with recurrent skin and sinopulmonary infections. Several features unrelated to immune system such as characteristic facial features, hyperextensibility of joints, multiple bone fractures and craniosynostosis have been described in the literature. We describe a rare presentation of this disease with invasive aspergillosis presenting as mediastinal mass with extension to mediastinal structures and pulmonary vasculature.

Original languageEnglish
Article number26074
JournalBMJ Case Reports
Publication statusPublished - 2018


  • dermatology
  • immunology
  • pneumonia (infectious disease)


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