Late-onset Familial Hemophagocytic Lymphohistiocytosis in a survivor of Hodgkin's Lymphoma

Mirza Rameez Samar, Daania Shoaib, Nida e Zehra, Munira Moosajee

Research output: Contribution to journalArticlepeer-review

Abstract

Hemophagocytic Lymphohistiocytosis is an inflammatory condition which results in over activation of the immune system. It could be either sporadic or familial. The familial subtype is linked with various genetic mutations and is commonly a disease of the young. Here we report a case of HLH in an adult, occurring in the background of a successfully treated hematological malignancy. Upon workup, he was also found to have pathogenic STXBP2 mutation, suggesting HLH of familial origin To date, only few cases of adult-onset familial HLH have been brought to light.

Original languageEnglish
Article number100394
JournalLeukemia Research Reports
DOIs
Publication statusAccepted/In press - 2023

Keywords

  • Adult-onset
  • Allogenic stem cell transplant
  • Familial
  • Hemophagocytic lymphohistiocytosis
  • Hodgkin's lymphoma
  • STXBP2 mutation

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