Lead encephalopathy in an adult opioid abuser

Fatima Suleman, Karima Shoukat, Ainan Arshad, Nadeem Ullah Khan, Usman Sheikh

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A 38-year-old man presented at the emergency department with abdominal pain, vomiting, generalised weakness and altered consciousness. He had been ingesting opioids for over 5 years and had several past hospital admissions for abdominal pain. His investigations showed deranged liver function tests, anaemia and basophilic stippling on the peripheral blood smear. Further investigations revealed a significant increase in the serum lead level. We started chelation with peroral penicillamine 250 mg every 6 hours for 2 days and switched to intramuscular dimercaprol 4 mg/kg every 12 hours and intravenous calcium ethylenediamine tetraacetic acid 50 mg/kg in two divided doses daily for the next 5 days. We then discharged him home; he had become clinically stable by that time. We repeated his lead level and followed him up in the clinic. In this report, we emphasise the consideration of lead toxicity in opioid abusers and bring to attention a rare way of lead chelation in resource-limited settings.

Original languageEnglish
JournalBMJ Case Reports
Issue number9
Publication statusPublished - 20 Sept 2021
Externally publishedYes


  • adult intensive care
  • exposures
  • toxicology


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