Learned helplessness in mice

Hymie Anisman; Zul Merali

doi:10.1007/978-1-60761-303-9_10

Learned helplessness in mice

Hymie Anisman
, Zul Merali

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Citations (Scopus)

Abstract

Exposure to inescapable shock provokes behavioral disturbances in subsequent shock-escape tests, as well as in other behavioral paradigms, including those that reflect anhedonia. The interference induced by inescapable shock using a yoked (triadic) paradigm has frequently been referred to as a "learned helplessness" paradigm. The interference effect, although attributed to cognitive factors by several investigators, has also been explained on the basis of neurochemical changes induced by the uncontrollable stressor. In the present report, we briefly describe the various theoretical positions concerning the interference effect induced by inescapable hock, describe procedures that can be used to investigate this phenomenon in mice, and provide caveats that might be considered in conducting these experiments.

Original language	English (UK)
Title of host publication	Mood and Anxiety Related Phenotypes in Mice
Subtitle of host publication	Characterization Using Behavioral Tests
Publisher	Humana Press
Pages	177-196
Number of pages	20
ISBN (Print)	9781607613022
DOIs	https://doi.org/10.1007/978-1-60761-303-9_10
Publication status	Published - 2009
Externally published	Yes

Publication series

Name	Neuromethods
Volume	42
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Coping
Depression
Helplessness
Triadic paradigm
Uncontrollable stressor

Access to Document

10.1007/978-1-60761-303-9_10

Cite this

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AU - Merali, Zul

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AB - Exposure to inescapable shock provokes behavioral disturbances in subsequent shock-escape tests, as well as in other behavioral paradigms, including those that reflect anhedonia. The interference induced by inescapable shock using a yoked (triadic) paradigm has frequently been referred to as a "learned helplessness" paradigm. The interference effect, although attributed to cognitive factors by several investigators, has also been explained on the basis of neurochemical changes induced by the uncontrollable stressor. In the present report, we briefly describe the various theoretical positions concerning the interference effect induced by inescapable hock, describe procedures that can be used to investigate this phenomenon in mice, and provide caveats that might be considered in conducting these experiments.

KW - Coping

KW - Depression

KW - Helplessness

KW - Triadic paradigm

KW - Uncontrollable stressor

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SN - 9781607613022

T3 - Neuromethods

SP - 177

EP - 196

BT - Mood and Anxiety Related Phenotypes in Mice

PB - Humana Press

ER -

Learned helplessness in mice

Abstract

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UN SDGs

Keywords

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