TY - JOUR
T1 - Lepra reactions
T2 - A study of 130 cases from Pakistan
AU - Tabassum, Saadia
AU - Zia, Mutaher
AU - Khoja, Adeel Akbar
AU - David, Juliet
AU - Iqbal, Muhammad
AU - Junaid, Muhammad
N1 - Publisher Copyright:
© 2021 Pakistan Medical Association. All rights reserved.
PY - 2021/10
Y1 - 2021/10
N2 - Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73%) were males and 35(27%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58%), with 40(53%) of them having type 1 reaction as the first episode and 36(47%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.
AB - Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73%) were males and 35(27%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58%), with 40(53%) of them having type 1 reaction as the first episode and 36(47%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.
KW - ENL
KW - Erythema nodosum leprosum
KW - Lepra reactions
KW - Leprosy
KW - Neuritis
KW - Peripheral neuropathy
KW - Type 1 reversal reactions
UR - http://www.scopus.com/inward/record.url?scp=85115261150&partnerID=8YFLogxK
U2 - 10.47391/JPMA.07-849
DO - 10.47391/JPMA.07-849
M3 - Article
C2 - 34974562
AN - SCOPUS:85115261150
SN - 0030-9982
VL - 71
SP - 2317
EP - 2320
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 10
ER -