Lepra reactions: A study of 130 cases from Pakistan

Saadia Tabassum; Mutaher Zia; Adeel Akbar Khoja; Juliet David; Muhammad Iqbal; Muhammad Junaid

doi:10.47391/JPMA.07-849

Lepra reactions: A study of 130 cases from Pakistan

Saadia Tabassum
, Mutaher Zia
, Adeel Akbar Khoja
, Juliet David
, Muhammad Iqbal
, Muhammad Junaid

Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73%) were males and 35(27%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58%), with 40(53%) of them having type 1 reaction as the first episode and 36(47%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.

Original language	English (US)
Pages (from-to)	2317-2320
Number of pages	4
Journal	Journal of the Pakistan Medical Association
Volume	71
Issue number	10
DOIs	https://doi.org/10.47391/JPMA.07-849
Publication status	Published - Oct 2021

Keywords

ENL
Erythema nodosum leprosum
Lepra reactions
Leprosy
Neuritis
Peripheral neuropathy
Type 1 reversal reactions

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10.47391/JPMA.07-849

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title = "Lepra reactions: A study of 130 cases from Pakistan",

abstract = "Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73\%) were males and 35(27\%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58\%), with 40(53\%) of them having type 1 reaction as the first episode and 36(47\%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.",

keywords = "ENL, Erythema nodosum leprosum, Lepra reactions, Leprosy, Neuritis, Peripheral neuropathy, Type 1 reversal reactions",

author = "Saadia Tabassum and Mutaher Zia and Khoja, \{Adeel Akbar\} and Juliet David and Muhammad Iqbal and Muhammad Junaid",

year = "2021",

month = oct,

doi = "10.47391/JPMA.07-849",

language = "English (US)",

volume = "71",

pages = "2317--2320",

journal = "Journal of the Pakistan Medical Association",

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T1 - Lepra reactions

T2 - A study of 130 cases from Pakistan

AU - Tabassum, Saadia

AU - Zia, Mutaher

AU - Khoja, Adeel Akbar

AU - David, Juliet

AU - Iqbal, Muhammad

AU - Junaid, Muhammad

PY - 2021/10

Y1 - 2021/10

N2 - Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73%) were males and 35(27%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58%), with 40(53%) of them having type 1 reaction as the first episode and 36(47%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.

AB - Objective: To determine the occurrence and characteristics of lepra reactions in leprosy patients. Methods: The retrospective study was conducted at the Marie Adelaide Leprosy Centre, Karachi, and comprised data of patients admitted between January 1, 2013, and December 31, 2015, for the management of lepra reactions. Data was noted on a detailed proforma and was analysed using Microsoft Excel and applying chi-square test. Results: Of the 130 cases, 95(73%) were males and 35(27%) were females. Mean age at onset of the first episode was 39±14 years. Borderline lepromatous was the most common classification 76(58%), with 40(53%) of them having type 1 reaction as the first episode and 36(47%) having a type 2 reaction Risk factors associated with recurrence were skin lesions, fever, lymphadenopathy and type of reaction (p<0.05). Conclusion: Healthcare providers need to be aware of the clinical manifestations of lepra reactions in order to diagnose them early.

KW - ENL

KW - Erythema nodosum leprosum

KW - Lepra reactions

KW - Leprosy

KW - Neuritis

KW - Peripheral neuropathy

KW - Type 1 reversal reactions

UR - https://www.scopus.com/pages/publications/85115261150

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DO - 10.47391/JPMA.07-849

M3 - Article

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AN - SCOPUS:85115261150

SN - 0030-9982

VL - 71

SP - 2317

EP - 2320

JO - Journal of the Pakistan Medical Association

JF - Journal of the Pakistan Medical Association

IS - 10

ER -

Lepra reactions: A study of 130 cases from Pakistan

Abstract

Keywords

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