Life's simple 7 and incident heart failure: The multi-ethnic study of atherosclerosis

Oluseye Ogunmoroti, Ebenezer Oni, Erin D. Michos, Erica S. Spatz, Norrina B. Allen, Jamal S. Rana, Salim S. Virani, Ron Blankstein, Konstantinos N. Aronis, Roger S. Blumenthal, Emir Veledar, Moyses Szklo, Michael J. Blaha, Khurram Nasir

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79 Citations (Scopus)


Background--The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We sought to examine the association between the LS7 metrics and incident heart failure (HF) in a multiethnic cohort. Methods and Results--We analyzed data from 6506 participants of the Multi-Ethnic Study of Atherosclerosis free of cardiovascular disease at baseline. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol, and blood glucose) were graded on a scale of 0 to 2, with 2 indicating "ideal" status, 1 "intermediate" status, and 0 "poor" status. Points were summed, thus the LS7 score ranged from 0 to 14. Cox proportional hazard ratios and incidence rates of HF per 1000 person-years were calculated. During a median follow-up of 12.2 years, 262 (4%) participants developed HF. Incidence of HF decreased as the number of ideal LS7 metrics increased; 5.9 per 1000 person-years for participants with 0 to 1 ideal metrics and 0.6 per 1000 person-years for those with 6 to 7 ideal metrics. Compared with inadequate scores (0-8 points), hazard ratios for HF were 0.57 (0.43-0.76) and 0.31 (0.19-0.49) for average (9-10 points) and optimal (11-14 points) scores, respectively. A similar pattern was observed when the results were stratified by 4 racial/ethnic groups: white, Chinese American, black, and Hispanic. Conclusions--A lower risk of HF with more favorable LS7 status regardless of race/ethnicity suggests that efforts to achieve ideal cardiovascular health may reduce the burden of HF, a major source of morbidity and mortality.

Original languageEnglish
Article numbere005180
JournalJournal of the American Heart Association
Issue number6
Publication statusPublished - 1 Jun 2017
Externally publishedYes


  • Cardiovascular disease prevention
  • Epidemiology
  • Heart failure
  • Ideal cardiovascular health metrics
  • Life's Simple 7
  • Risk factor


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