Lifestyle Approach and Medical Therapy of Lower Extremity Peripheral Artery Disease

Chayakrit Krittanawong, Johao Escobar, Hafeez Ul Hassan Virk, Mahboob Alam, Salim Virani, Carl J. Lavie, K. M.Venkat Narayan, Raman Sharma

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Lower extremity peripheral artery disease (PAD) is common among patients with several risk factors, such as elderly, smoking, hypertension, and diabetes mellitus. Notably, PAD is associated with a higher risk of cardiovascular complications. Non-invasive interventions are beneficial to improve morbidity and mortality among patients with PAD. Traditional risk factors like smoking, diabetes mellitus, hypertension, and dyslipidemia play a significant role in the development of PAD. Still, additional factors such as mental health, glycemic control, diet, exercise, obesity management, lipid-lowering therapy, and antiplatelet therapy have emerged as important considerations. Managing these factors can help improve outcomes and reduce complications in PAD patients. Antiplatelet therapy with aspirin or clopidogrel is recommended in PAD patients, with clopidogrel showing more significant benefits in symptomatic PAD individuals. Managing several risk factors is crucial for improving outcomes and reducing complications in patients with PAD. Further research is also needed to explore the potential benefits of novel therapies. Ultimately, a comprehensive approach to PAD management is essential for improving morbidity and mortality among patients with this condition.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalAmerican Journal of Medicine
Issue number3
Publication statusPublished - Mar 2024


  • Lifestyle approach
  • Lifestyle medicine
  • PAD
  • Peripheral artery disease


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