Lipoblastoma: A clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature

Jamshid Abdul-Ghafar, Zubair Ahmad, Muhammad Usman Tariq, Naila Kayani, Nasir Uddin

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


Objective: Lipoblastoma is a rare neoplasm that occurs mostly in infants and children. Although benign, it has a tendency for local recurrence. Results: Clinical and pathological features of 23 cases of lipoblastoma described. Patients' age ranged from 8 months to 18 years with mean and median age 4.1 and 2.5 years, respectively. Male:female ratio was 2.8:1. Most common sites were lower extremities (9 cases), followed by abdominal cavity and retroperitoneum (4 cases), and scrotum/groin (3 cases). Grossly, 22 tumors were well circumscribed and multi nodular. All cases showed lobules composed of adipocytes and lipoblasts with intervening fibrous septa and fine vascular network. Myxoid change, capsule formation and septation were seen in all cases. Zonation was seen in 2 cases. Follow-up was available in 14 out of 23 patients. Of these, 13 were alive and free of disease with no evidence of any recurrent lesion. One patient with a mediastinal infiltrating lipoblastoma experienced 4 recurrences. Lipoblastoma is a benign adipocytic neoplasm of infants and young children. Correlation of clinical and histological features helps in reaching a correct diagnosis. Owing to a high recurrence rate following incomplete resection, a complete resection is essential. Prognosis is excellent after complete resection.

Original languageEnglish
Article number42
JournalBMC Research Notes
Issue number1
Publication statusPublished - 17 Jan 2018


  • Adipocyte
  • Benign
  • Lipoblastoma
  • Recurrence


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