Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure

Rajiv Jalan, Anthony Pollok, Syed H.A. Shah, Krishna K. Madhavan, Kenneth J. Simpson

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

We describe a patient with paracetamol induced acute liver failure (ALF) who fulfilled criteria for poor prognosis and was waiting for a liver to become available for transplantation. Because of severe uncontrolled intracranial hypertension she underwent a hepatectomy that resulted in stabilization of her systemic and cerebral hemodynamics. She remained anhepatic for 14 h and was successfully bridged to liver transplantation. The removal of the liver was associated with a sharp and sustained reduction in the circulating pro-inflammatory cytokine concentration suggesting that liver derived pro-inflammatory cytokines may be important in the pathogenesis of intracranial hypertension in patients with ALF.

Original languageEnglish
Pages (from-to)536-538
Number of pages3
JournalJournal of Hepatology
Volume37
Issue number4
DOIs
Publication statusPublished - Oct 2002
Externally publishedYes

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