Local treatment of bacterial vaginosis with a bioadhesive metronidazole tablet

Jody Voorspoels, Martine Casteels, Jean Paul Remon, Marleen Temmerman

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Objectives: Oral metronidazole is still the drug of choice in the treatment of bacterial vaginosis. Yet, side effects have been reported, and dosage as well as duration of therapy are still controversial. This study presents a possible alternative treatment using a single dose of metronidazole administered in a vaginal bioadhesive tablet. Study design: Double blind, randomised, placebo-controlled trial. Subjects: The 116 patients were allocated to placebo; metronidazole 100; 250; 500mg in a 1:1:1:1 ratio. Results: A cure rate of 64% was obtained with a single 100mg dose of metronidazole formulated in a bioadhesive vaginal tablet compared to a cure rate of 29% in the placebo group. The cure rates with the higher doses were similar 61.5% for 250mg dose and 68% for the 500mg dose. No side effects were reported. Conclusions: Treatment of bacterial vaginosis with a single application of 100mg metronidazole in a bioadhesive vaginal tablet was found to be a valid alternative. Further research in relation to tablet shaping and optimal dose finding might increase the cure rate.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 10 Oct 2002
Externally publishedYes


  • Bacterial vaginosis
  • Bioadhesive tablet
  • Local treatment


Dive into the research topics of 'Local treatment of bacterial vaginosis with a bioadhesive metronidazole tablet'. Together they form a unique fingerprint.

Cite this