Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Ann Quaghebeur; Lillian Mutunga; Fabian Mwanyumba; Kishor Mandaliya; Chris Verhofstede; Marleen Temmerman

doi:10.1097/00002030-200409030-00018

Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Ann Quaghebeur, Lillian Mutunga, Fabian Mwanyumba, Kishor Mandaliya, Chris Verhofstede, Marleen Temmerman

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.

Original language	English
Pages (from-to)	1854-1856
Number of pages	3
Journal	AIDS
Volume	18
Issue number	13
DOIs	https://doi.org/10.1097/00002030-200409030-00018
Publication status	Published - 3 Sept 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/00002030-200409030-00018

Cite this

@article{469e82c351964379b4fc0d5ccfd326da,

title = "Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation",

abstract = "Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.",

author = "Ann Quaghebeur and Lillian Mutunga and Fabian Mwanyumba and Kishor Mandaliya and Chris Verhofstede and Marleen Temmerman",

year = "2004",

month = sep,

day = "3",

doi = "10.1097/00002030-200409030-00018",

language = "English",

volume = "18",

pages = "1854--1856",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "13",

}

TY - JOUR

T1 - Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

AU - Quaghebeur, Ann

AU - Mutunga, Lillian

AU - Mwanyumba, Fabian

AU - Mandaliya, Kishor

AU - Verhofstede, Chris

AU - Temmerman, Marleen

PY - 2004/9/3

Y1 - 2004/9/3

N2 - Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.

AB - Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.

UR - http://www.scopus.com/inward/record.url?scp=4444243811&partnerID=8YFLogxK

U2 - 10.1097/00002030-200409030-00018

DO - 10.1097/00002030-200409030-00018

M3 - Article

C2 - 15316350

AN - SCOPUS:4444243811

SN - 0269-9370

VL - 18

SP - 1854

EP - 1856

JO - AIDS

JF - AIDS

IS - 13

ER -

Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this