Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Ann Quaghebeur; Lillian Mutunga; Fabian Mwanyumba; Kishor Mandaliya; Chris Verhofstede; Marleen Temmerman

doi:10.1097/00002030-200409030-00018

Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Ann Quaghebeur
, Lillian Mutunga
, Fabian Mwanyumba
, Kishor Mandaliya
, Chris Verhofstede
, Marleen Temmerman

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.

Original language	English (US)
Pages (from-to)	1854-1856
Number of pages	3
Journal	AIDS
Volume	18
Issue number	13
DOIs	https://doi.org/10.1097/00002030-200409030-00018
Publication status	Published - 3 Sept 2004
Externally published	Yes

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10.1097/00002030-200409030-00018

Cite this

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AU - Mwanyumba, Fabian

AU - Mandaliya, Kishor

AU - Verhofstede, Chris

AU - Temmerman, Marleen

PY - 2004/9/3

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AB - Since 2001, the unrestricted use of HIVNET012 has been recommended for the prevention of mother-to-child transmission in low-resource settings, despite the lack of validated efficacy data outside research settings. We implemented the nevirapine regimen in a real-life situation in Kenya. The perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention. These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.

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Low efficacy of nevirapine (HIVNET012) in preventing perinatal HIV-1 transmission in a real-life situation

Abstract

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