Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course

Nasir Ud Din, Melike Pekmezci, Gohar Javed, Andrew E. Horvai, Zubair Ahmad, Muhammad Faheem, Anthony L. Navarro, Dolores López-Terrada, Arie Perry

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

We report a case of a longstanding, large tumor involving spinal nerve roots of the cauda equina. The tumor showed small round cells arranged in nests and cords and immunophenotypic features of a glomus tumor, along with infrequent mitoses and a low Ki-67 labeling index, but exhibited some rosette-like structures, with focal CD99 and Neu-N expression. Subsequent molecular analysis showed the presence of an EWSR1-WT1 gene fusion by fluorescence in situ hybridization, which was confirmed by reverse- transcriptase polymerase chain reaction. To our knowledge, this is the first case reported with EWSR1-WT1 fusion in a small round blue cell tumor with smooth muscle differentiation and an indolent course.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalHuman Pathology
Volume46
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Bilateral
  • Desmoplastic small round cell tumor
  • EWSR1
  • EWSR1-WT1
  • Glomus tumor
  • Spinal nerves

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