Lymphomatosis Cerebri: A diagnostic dilemma

Sibgha Khan, Fatima Mubarak, Khurram Minhas, Dureshahwar Kanwar, Robert Chun Chen

Research output: Contribution to journalArticlepeer-review


Background: Lymphomatosis cerebri (LC) is a rare manifestation of primary central nervous system lymphoma (PCNSL) with only a few cases reported in the literature, appearing as diffuse infiltrating process rather than a solitary mass. It is a non-Hodgkin’s type of lymphoma and is usually of the B-cell type origin. Purpose: We intend to report this unique case of LC which came across as a diagnostic challenge. Methods: A 53-year-old gentleman presented with complaints of two episodes of seizures 24 h apart followed by postictal confusion for 10–15 min. He underwent multiple MRI scans and underwent a biopsy of the lesion which reported infection, but he did not benefit from the treatment. Result: The imaging was reviewed, suspicion of LC was raised and a review of histopathology was requested which later confirmed primary CNS lymphoma. Conclusion: LC is a rare but established manifestation of PCNSL which mimics multiple other conditions. Understanding of the imaging pattern is important in making the diagnosis and differentiating it from other mimic conditions.

Original languageEnglish
JournalAnnals of Neurosciences
Publication statusAccepted/In press - 2023


  • Clinical neuroscience
  • behaviour
  • clinical medicine
  • function
  • neurology


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