TY - JOUR
T1 - Magnitude of vancomycin resistant enterococcus fecal colonization and bacteremia in patients with hematological diseases at tertiary bone marrow transplant centre Rawalpindi
AU - Sabir, Nargis
AU - Satti, Luqman
AU - Ahmed, Abeera
AU - Zaman, Gohar
AU - Iftikhar, Raheel
AU - Uddin, Nasir
N1 - Publisher Copyright:
© 2021, Army Medical College. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective: To discover the frequency of vancomycin resistant enterococci (VRE) fecal colonization and subsequent bacteremia in patients with hematological diseases in a bone marrow transplant center. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology (AFIP), in collaboration with Armed Forces Bone Marrow Transplant Center, Rawalpindi, from Jan 2016 to Dec 2019. Methodology: Stool specimens/anal swabs from all enrolled patients were collected aseptically and transported to the laboratory without delay. Blood cultures were collected aseptically from only those enrolled patients who developed signs and symptoms of bacteremia. Stool and blood cultures were processed as per standard microbiological protocols. Enterococci were identified to species level by colony morphology and biochemical tests. Modified Kirby Bauer disc diffusion method and VITEK-2 system (Version-8.01 bio Merieux, France) were used to perform antimicrobial sensitivity of each isolate. Results: A total number of 246 patients were studied. Among them, 67 (27%) patients had fecal colonization by vancomycin resistant enterococci. We report a statistically significant association of recent hospitalization, prolonged exposure to anti-microbial therapy, chemotherapy exposure and use of indwelling devices during the hospital stay with vancomycin resistant enterococci colonization. Vancomycin resistant enterococci bacteremia was detected in 57 (23%) patients. Among these 57 patients, 53 (93%) were vancomycin resistant enterococci colonizers. Vancomycin resistant enterococci colonization was significantly associated with vancomycin resistant enterococci bacteremia. Conclusion: A considerable burden of vancomycin resistant enterococci fecal colonization exists among patients with hemato-logical diseases. vancomycin resistant enterococci colonization poses a considerable risk of vancomycin resistant enterococci bloodstream infections in this patient population.
AB - Objective: To discover the frequency of vancomycin resistant enterococci (VRE) fecal colonization and subsequent bacteremia in patients with hematological diseases in a bone marrow transplant center. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology (AFIP), in collaboration with Armed Forces Bone Marrow Transplant Center, Rawalpindi, from Jan 2016 to Dec 2019. Methodology: Stool specimens/anal swabs from all enrolled patients were collected aseptically and transported to the laboratory without delay. Blood cultures were collected aseptically from only those enrolled patients who developed signs and symptoms of bacteremia. Stool and blood cultures were processed as per standard microbiological protocols. Enterococci were identified to species level by colony morphology and biochemical tests. Modified Kirby Bauer disc diffusion method and VITEK-2 system (Version-8.01 bio Merieux, France) were used to perform antimicrobial sensitivity of each isolate. Results: A total number of 246 patients were studied. Among them, 67 (27%) patients had fecal colonization by vancomycin resistant enterococci. We report a statistically significant association of recent hospitalization, prolonged exposure to anti-microbial therapy, chemotherapy exposure and use of indwelling devices during the hospital stay with vancomycin resistant enterococci colonization. Vancomycin resistant enterococci bacteremia was detected in 57 (23%) patients. Among these 57 patients, 53 (93%) were vancomycin resistant enterococci colonizers. Vancomycin resistant enterococci colonization was significantly associated with vancomycin resistant enterococci bacteremia. Conclusion: A considerable burden of vancomycin resistant enterococci fecal colonization exists among patients with hemato-logical diseases. vancomycin resistant enterococci colonization poses a considerable risk of vancomycin resistant enterococci bloodstream infections in this patient population.
KW - Antimicrobial susceptibility
KW - Hematological diseases
KW - Vancomycin resistant enterococci bacteremia
KW - Vancomycin resistant enterococci colonization
UR - http://www.scopus.com/inward/record.url?scp=85118649223&partnerID=8YFLogxK
U2 - 10.51253/pafmj.v71i4.4768
DO - 10.51253/pafmj.v71i4.4768
M3 - Article
AN - SCOPUS:85118649223
SN - 0030-9648
VL - 71
SP - 1142
EP - 1146
JO - Pakistan Armed Forces Medical Journal
JF - Pakistan Armed Forces Medical Journal
IS - 4
ER -