TY - JOUR
T1 - Maternal nutritional risk factors for pre-eclampsia incidence
T2 - findings from a narrative scoping review
AU - The PRECISE Conceptual Framework Working Group
AU - Kinshella, Mai Lei Woo
AU - Omar, Shazmeen
AU - Scherbinsky, Kerri
AU - Vidler, Marianne
AU - Magee, Laura A.
AU - von Dadelszen, Peter
AU - Moore, Sophie E.
AU - Elango, Rajavel
AU - Poston, Lucilla
AU - Mistry, Hiten D.
AU - Volvert, Marie Laure
AU - Lopez, Cristina Escalona
AU - Moore, Sophie
AU - Tribe, Rachel
AU - Shennan, Andrew
AU - Salisbury, Tatiana
AU - Chappell, Lucy
AU - Craik, Rachel
AU - Temmerman, Marleen
AU - Etyang, Angela Koech
AU - Wanyonyi, Sikolia
AU - Omuse, Geoffrey
AU - Okiro, Patricia
AU - Mwashigadi, Grace
AU - Sevene, Esperança
AU - Boene, Helena
AU - Tchavana, Corssino
AU - Macete, Eusebio
AU - Carillho, Carla
AU - Quimice, Lazaro
AU - Maculuve, Sonia
AU - Russell, Donna
AU - Baratt, Ben
AU - Lawn, Joy
AU - Blencowe, Hannah
AU - Filippi, Veronique
AU - Silver, Matt
AU - Makanga, Prestige Tatenda
AU - Makacha, Liberty
AU - Dube, Yolisa
AU - Nyapwere, Newton
AU - Mlambo, Reason
AU - D’Alessandro, Umberto
AU - Roca, Anna
AU - Martinez-Alvarez, Melisa
AU - Jah, Hawanatu
AU - Diallo, Brahima
AU - Sesay, Abdul Karim
AU - Touray, Fatima
AU - Sillah, Abdoulie
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the maternal cardiovascular and metabolic systems. As nutrition is important to support optimal development of the placenta and for the developing fetus, maternal diets may play a role in preventing pre-eclampsia. The purpose of this scoping review is to map the maternal nutritional deficiencies and imbalances associated with pre-eclampsia incidence and discuss evidence consistency and linkages with current understandings of the etiology of pre-eclampsia. Methods: A narrative scoping review was conducted to provide a descriptive account of available research, summarize research findings and identify gaps in the evidence base. Relevant observational studies and reviews of observational studies were identified in an iterative two-stage process first involving electronic database searches then more sensitive searches as familiarity with the literature increased. Results were considered in terms of their consistency of evidence, effect sizes and biological plausibility. Results: The review found evidence for associations between nutritional inadequacies and a greater risk of pre-eclampsia. These associations were most likely mediated through oxidative stress, inflammation, maternal endothelial dysfunction and blood pressure in the pathophysiology of pre-eclampsia. Maternal nutritional risk factors for pre-eclampsia incidence with the strongest consistency, effect and biological plausibility include vitamin C and its potential relationship with iron status, vitamin D (both on its own and combined with calcium and magnesium), and healthy dietary patterns featuring high consumption of fruits, vegetables, whole grains, fish, seafood and monounsaturated vegetable oils. Foods high in added sugar, such as sugary drinks, were associated with increased risk of pre-eclampsia incidence. Conclusion: A growing body of literature highlights the involvement of maternal dietary factors in the development of pre-eclampsia. Our review findings support the need for further investigation into potential interactions between dietary factors and consideration of nutritional homeostasis and healthy dietary patterns. Further research is recommended to explore gestational age, potential non-linear relationships, dietary diversity and social, cultural contexts of food and meals.
AB - Background: Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the maternal cardiovascular and metabolic systems. As nutrition is important to support optimal development of the placenta and for the developing fetus, maternal diets may play a role in preventing pre-eclampsia. The purpose of this scoping review is to map the maternal nutritional deficiencies and imbalances associated with pre-eclampsia incidence and discuss evidence consistency and linkages with current understandings of the etiology of pre-eclampsia. Methods: A narrative scoping review was conducted to provide a descriptive account of available research, summarize research findings and identify gaps in the evidence base. Relevant observational studies and reviews of observational studies were identified in an iterative two-stage process first involving electronic database searches then more sensitive searches as familiarity with the literature increased. Results were considered in terms of their consistency of evidence, effect sizes and biological plausibility. Results: The review found evidence for associations between nutritional inadequacies and a greater risk of pre-eclampsia. These associations were most likely mediated through oxidative stress, inflammation, maternal endothelial dysfunction and blood pressure in the pathophysiology of pre-eclampsia. Maternal nutritional risk factors for pre-eclampsia incidence with the strongest consistency, effect and biological plausibility include vitamin C and its potential relationship with iron status, vitamin D (both on its own and combined with calcium and magnesium), and healthy dietary patterns featuring high consumption of fruits, vegetables, whole grains, fish, seafood and monounsaturated vegetable oils. Foods high in added sugar, such as sugary drinks, were associated with increased risk of pre-eclampsia incidence. Conclusion: A growing body of literature highlights the involvement of maternal dietary factors in the development of pre-eclampsia. Our review findings support the need for further investigation into potential interactions between dietary factors and consideration of nutritional homeostasis and healthy dietary patterns. Further research is recommended to explore gestational age, potential non-linear relationships, dietary diversity and social, cultural contexts of food and meals.
UR - http://www.scopus.com/inward/record.url?scp=85137195623&partnerID=8YFLogxK
U2 - 10.1186/s12978-022-01485-9
DO - 10.1186/s12978-022-01485-9
M3 - Review article
C2 - 36064716
AN - SCOPUS:85137195623
SN - 1742-4755
VL - 19
JO - Reproductive Health
JF - Reproductive Health
IS - 1
M1 - 188
ER -