Mechanism of neuronal injury in cerebral venous thrombosis

Uzma Usman, Mohammad Wasay

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


The impact of CVT on the brain is wide spectrum, ranging from completely normal parenchyma to brain oedema and/or haemorrhage. Multiple factors relate to neuronal injury in CVT including; dural sinus pressure, increased venous flow velocities, collateralization of venous channels, rate of occlusion, development of cytotoxic and vasogenic oedema, recanalization and accelerated myelination. It is suggested that recanalization of occluded vein, as well as, the presence or absence and the efficiency of intracranial venous collaterals, may have an impact on the extent of brain tissue damage and hence the prognosis of acute CVT.

Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalJournal of the Pakistan Medical Association
Issue number11
Publication statusPublished - Nov 2006


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