Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases

Qurat Ul Ain Tariq; Eisha Abid Ali; Noman Ahmad; Saad-bin Anis; Irfan Yousaf; Muhammad Shahzad Shamim

doi:10.47391/JPMA.25-65

Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases

Qurat Ul Ain Tariq, Eisha Abid Ali, Noman Ahmad, Saad-bin Anis, Irfan Yousaf, Muhammad Shahzad Shamim

Research output: Contribution to journal › Article

Abstract

Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.

Original language	Undefined/Unknown
Pages (from-to)	1304-1306
Number of pages	3
Journal	Journal of the Pakistan Medical Association
Volume	75
Issue number	8
DOIs	https://doi.org/10.47391/JPMA.25-65
Publication status	Published - 1 Aug 2025

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http://ecommons.aku.edu/pakistan_fhs_mc_surg_neurosurg/420

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title = "Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases",

abstract = "Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.",

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AU - Tariq, Qurat Ul Ain

AU - Ali, Eisha Abid

AU - Ahmad, Noman

AU - Anis, Saad-bin

AU - Yousaf, Irfan

AU - Shamim, Muhammad Shahzad

PY - 2025/8/1

Y1 - 2025/8/1

N2 - Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.

AB - Breast cancer brain metastases (BCBM) are a significant clinical challenge, especially in aggressive subtypes like HER2-positive and triple-negative breast cancer. This review discusses hormone receptor discordance, it's existence and contributing factors, the role of the bloodbrain barrier (BBB) in metastatic progression, and therapeutic modalities. While local treatments such as surgery and radiotherapy remain foundational, advances in systemic and immunotherapeutic approaches show promising potential. A deeper understanding of molecular mechanisms driving BCBM is essential to guide effective treatments and improve patient outcomes.

UR - https://www.scopus.com/pages/publications/105014535010

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DO - 10.47391/JPMA.25-65

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JO - Journal of the Pakistan Medical Association

JF - Journal of the Pakistan Medical Association

IS - 8

ER -

Mirror image or molecular mirage? Investigating hormone receptor disconcordance in breast cancer brain metastases

Abstract

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