Monitoring technologies in the neonatal intensive care unit: Implications for the detection of necrotizing enterocolitis

Necrotizing enterocolitis is the most common and fulminant gastrointestinal disease affecting neonates. Its pathogenesis is heterogeneous and not clearly understood. Early detection could prevent some of the devastating consequences of this disease, but currently there is no noninvasive method of reliable early-stage detection. Here, we review various noninvasive monitoring technologies that have already been employed or show promise for early detection. Each method may have an important role after its technical difficulties are resolved. These are discussed in detail as they relate to various aspects of the putative pathophysiology of this devastating disease.