MUC 1: A genetic susceptibility to infertility?

Andrew W. Horne; John O. White; Raul A. Margara; Ross Williams; Robert M.L. Winston; El Nasir Lalani

doi:10.1016/S0140-6736(00)04502-5

MUC 1: A genetic susceptibility to infertility?

Andrew W. Horne, John O. White, Raul A. Margara, Ross Williams, Robert M.L. Winston, El Nasir Lalani

Research output: Contribution to journal › Article › peer-review

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Abstract

In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2·5 kb compared with 3·4 kb in the fertile group (p = 0·0029, difference 0·9, [95% CI 0·1-1·3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.

Original language	English
Pages (from-to)	1336-1337
Number of pages	2
Journal	The Lancet
Volume	357
Issue number	9265
DOIs	https://doi.org/10.1016/S0140-6736(00)04502-5
Publication status	Published - 28 Apr 2001
Externally published	Yes

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title = "MUC 1: A genetic susceptibility to infertility?",

abstract = "In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2·5 kb compared with 3·4 kb in the fertile group (p = 0·0029, difference 0·9, [95% CI 0·1-1·3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.",

author = "Horne, {Andrew W.} and White, {John O.} and Margara, {Raul A.} and Ross Williams and Winston, {Robert M.L.} and Lalani, {El Nasir}",

note = "Funding Information: We thank Prof Gordon Stamp, Geoffrey Trew, and Megan Hitchins for their encouragement and suggestions. The work was supported by a grant from the Medical Research Council, London (Ref G84/5342).",

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T2 - A genetic susceptibility to infertility?

AU - Horne, Andrew W.

AU - White, John O.

AU - Margara, Raul A.

AU - Williams, Ross

AU - Winston, Robert M.L.

AU - Lalani, El Nasir

N1 - Funding Information: We thank Prof Gordon Stamp, Geoffrey Trew, and Megan Hitchins for their encouragement and suggestions. The work was supported by a grant from the Medical Research Council, London (Ref G84/5342).

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Y1 - 2001/4/28

N2 - In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2·5 kb compared with 3·4 kb in the fertile group (p = 0·0029, difference 0·9, [95% CI 0·1-1·3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.

AB - In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2·5 kb compared with 3·4 kb in the fertile group (p = 0·0029, difference 0·9, [95% CI 0·1-1·3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.

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DO - 10.1016/S0140-6736(00)04502-5

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MUC 1: A genetic susceptibility to infertility?

Abstract

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