Mucosal Immunity to Poliovirus in Children 0-15 Years of Age: A Community-Based Study in Karachi, Pakistan in 2019

Ali Faisal Saleem; Zaubina Umar Kazi; Syeda Mahjabeen Zehra; Sadia Parkar; Grace Macklin; Giovanna Sifontes; Bernardo A. Mainou; Masroor Alam; Rocio Lopez Cavestany; Ondrej Mach

doi:10.1093/infdis/jiae006

Mucosal Immunity to Poliovirus in Children 0-15 Years of Age: A Community-Based Study in Karachi, Pakistan in 2019

Ali Faisal Saleem, Zaubina Umar Kazi, Syeda Mahjabeen Zehra, Sadia Parkar, Grace Macklin, Giovanna Sifontes, Bernardo A. Mainou, Masroor Alam, Rocio Lopez Cavestany, Ondrej Mach

Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

This study assesses poliovirus type 1 (PV1) immunity in children to inform the contribution of mucosal immunity in and prevention of poliovirus circulation. A community-based study was conducted in periurban Karachi, Pakistan. Randomly selected children (0-15 years of age) received oral poliovirus vaccine (OPV) challenge dose. Blood and stool samples were collected at several time points and evaluated for polio-neutralizing antibodies and serotype-specific poliovirus, respectively. Eighty-one of 589 (14%) children excreted PV1 7 days post-OPV challenge; 70 of 81 (86%) were seropositive at baseline. Twelve of 610 (2%) were asymptomatic wild poliovirus type 1 (WPV1) excretors. Most poliovirus excretors had humoral immunity, suggesting mucosal immunity in these children likely waned or never developed. Without mucosal immunity, they are susceptible to poliovirus infection, shedding, and transmission. Asymptomatic WPV1 excretion suggests undetected poliovirus circulation within the community.

Original language	English
Pages (from-to)	736-740
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	230
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiae006
Publication status	Published - 15 Sept 2024

Keywords

humoral immunity
mucosal immunity
Pakistan
poliovirus
viral shedding

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiae006

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title = "Mucosal Immunity to Poliovirus in Children 0-15 Years of Age: A Community-Based Study in Karachi, Pakistan in 2019",

abstract = "This study assesses poliovirus type 1 (PV1) immunity in children to inform the contribution of mucosal immunity in and prevention of poliovirus circulation. A community-based study was conducted in periurban Karachi, Pakistan. Randomly selected children (0-15 years of age) received oral poliovirus vaccine (OPV) challenge dose. Blood and stool samples were collected at several time points and evaluated for polio-neutralizing antibodies and serotype-specific poliovirus, respectively. Eighty-one of 589 (14%) children excreted PV1 7 days post-OPV challenge; 70 of 81 (86%) were seropositive at baseline. Twelve of 610 (2%) were asymptomatic wild poliovirus type 1 (WPV1) excretors. Most poliovirus excretors had humoral immunity, suggesting mucosal immunity in these children likely waned or never developed. Without mucosal immunity, they are susceptible to poliovirus infection, shedding, and transmission. Asymptomatic WPV1 excretion suggests undetected poliovirus circulation within the community.",

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AU - Macklin, Grace

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AU - Lopez Cavestany, Rocio

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Mucosal Immunity to Poliovirus in Children 0-15 Years of Age: A Community-Based Study in Karachi, Pakistan in 2019

Abstract

Keywords

UN SDGs

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