Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes

Xin Tang; Salahuddin Ahmed; Farzana Bashir Ahmed; Vincent Albrecht; Vincenth Brennsteiner; Alan Lee Chang; Nabidul Haque Chowdhury; Saikat Deb; Matthew Gormley; Tarik Hasan; Leah Kamulaza; Javairia Khalid; Waqasuddin Khan; Rasheda Khanam; Pallavi Kshetrapal; Hanqi Luo; Tushar K. Maiti; Arindam Maitra; Mohammad Mohsin Mannan; Johannes Mueller-Reif; Clyde Mulenga; Imran Nisar; Jesmin Pervin; Teeranan Pokaprakarn; Joni Price; Muhammad F. Qazi; Katelyn Rittenhouse; Yuri Sebastiao; Ntazana Sindano; Tulika Sinha; Shailaja Sopory; Medini Steger; Ramachandran Thiruvengadam; Nitya Wadhwa; Lei Xue; Nima Aghaeepour; Abdullah H. Baqui; Shinjini Bhatnagar; Susan Fisher; Melissa Fox; Daniela Hampel; Margaret Kasaro; Matthias Mann; Anisur Rahman; Sunil Sazawal; Liat Shenhav; Jeffrey Sa Stringer; Ge Zhang; Fyezah Jehan; Kristina De Paris

doi:10.7189/jogh.16.05002

Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes

Xin Tang
, Salahuddin Ahmed
, Farzana Bashir Ahmed
, Vincent Albrecht
, Vincenth Brennsteiner
, Alan Lee Chang
, Nabidul Haque Chowdhury
, Saikat Deb
, Matthew Gormley
, Tarik Hasan
, Leah Kamulaza
, Javairia Khalid
, Waqasuddin Khan
, Rasheda Khanam
, Pallavi Kshetrapal
, Hanqi Luo
, Tushar K. Maiti
, Arindam Maitra
, Mohammad Mohsin Mannan
, Johannes Mueller-Reif

Clyde Mulenga, Imran Nisar, Jesmin Pervin, Teeranan Pokaprakarn, Joni Price, Muhammad F. Qazi, Katelyn Rittenhouse, Yuri Sebastiao, Ntazana Sindano, Tulika Sinha, Shailaja Sopory, Medini Steger, Ramachandran Thiruvengadam, Nitya Wadhwa, Lei Xue, Nima Aghaeepour, Abdullah H. Baqui, Shinjini Bhatnagar, Susan Fisher, Melissa Fox, Daniela Hampel, Margaret Kasaro, Matthias Mann, Anisur Rahman, Sunil Sazawal, Liat Shenhav, Jeffrey Sa Stringer, Ge Zhang, Fyezah Jehan, Kristina De Paris

Department of Paediatrics and Child Health, Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in low- and middle-income countries (LMICs). The MOMI Consortium consists of six different LMIC sites established by The Alliance for Maternal and Newborn Health Improvement in Bangladesh, Pakistan, and Tanzania, the Global Alliance to Prevent Prematurity and Stillbirth in Bangladesh and Zambia, and the Interdisciplinary Group for Advanced Research on Birth Outcomes - DBT India Initiative. It also partners with five analytical partners and three bioinformatic teams. Methods: The combined MOMI cohort includes 24 321 pregnant women, a rich biorepository, and paired socioeconomic and clinical data. Considering the multifactorial aetiologies and molecular drivers of APOs, we applied an integrative multi-omics (genomics, metabolomics, proteomics, nutrient testing) approach to identify site-specific and cohort-wide signatures linked to distinct APOs. Conclusions: This protocol summarises the MOMI study design, sample and data collection methods, data harmonisation, and the various analytics platforms, and discusses potential outcomes for enhanced clinical care and novel diagnostic and therapeutic tools.

Original language	English (US)
Pages (from-to)	5002
Number of pages	1
Journal	Journal of Global Health
Volume	16
DOIs	https://doi.org/10.7189/jogh.16.05002
Publication status	Published - 3 Apr 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.7189/jogh.16.05002

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Tang, X., Ahmed, S., Ahmed, F. B., Albrecht, V., Brennsteiner, V., Chang, A. L., Chowdhury, N. H., Deb, S., Gormley, M., Hasan, T., Kamulaza, L., Khalid, J., Khan, W., Khanam, R., Kshetrapal, P., Luo, H., Maiti, T. K., Maitra, A., Mannan, M. M., ... De Paris, K. (2026). Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes. Journal of Global Health, 16, 5002. https://doi.org/10.7189/jogh.16.05002

@article{96adba0afbae4d80af898ae8c3f32544,

title = "Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes",

abstract = "Background: The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in low- and middle-income countries (LMICs). The MOMI Consortium consists of six different LMIC sites established by The Alliance for Maternal and Newborn Health Improvement in Bangladesh, Pakistan, and Tanzania, the Global Alliance to Prevent Prematurity and Stillbirth in Bangladesh and Zambia, and the Interdisciplinary Group for Advanced Research on Birth Outcomes - DBT India Initiative. It also partners with five analytical partners and three bioinformatic teams. Methods: The combined MOMI cohort includes 24 321 pregnant women, a rich biorepository, and paired socioeconomic and clinical data. Considering the multifactorial aetiologies and molecular drivers of APOs, we applied an integrative multi-omics (genomics, metabolomics, proteomics, nutrient testing) approach to identify site-specific and cohort-wide signatures linked to distinct APOs. Conclusions: This protocol summarises the MOMI study design, sample and data collection methods, data harmonisation, and the various analytics platforms, and discusses potential outcomes for enhanced clinical care and novel diagnostic and therapeutic tools.",

author = "Xin Tang and Salahuddin Ahmed and Ahmed, \{Farzana Bashir\} and Vincent Albrecht and Vincenth Brennsteiner and Chang, \{Alan Lee\} and Chowdhury, \{Nabidul Haque\} and Saikat Deb and Matthew Gormley and Tarik Hasan and Leah Kamulaza and Javairia Khalid and Waqasuddin Khan and Rasheda Khanam and Pallavi Kshetrapal and Hanqi Luo and Maiti, \{Tushar K.\} and Arindam Maitra and Mannan, \{Mohammad Mohsin\} and Johannes Mueller-Reif and Clyde Mulenga and Imran Nisar and Jesmin Pervin and Teeranan Pokaprakarn and Joni Price and Qazi, \{Muhammad F.\} and Katelyn Rittenhouse and Yuri Sebastiao and Ntazana Sindano and Tulika Sinha and Shailaja Sopory and Medini Steger and Ramachandran Thiruvengadam and Nitya Wadhwa and Lei Xue and Nima Aghaeepour and Baqui, \{Abdullah H.\} and Shinjini Bhatnagar and Susan Fisher and Melissa Fox and Daniela Hampel and Margaret Kasaro and Matthias Mann and Anisur Rahman and Sunil Sazawal and Liat Shenhav and Stringer, \{Jeffrey Sa\} and Ge Zhang and Fyezah Jehan and \{De Paris\}, Kristina",

year = "2026",

month = apr,

day = "3",

doi = "10.7189/jogh.16.05002",

language = "English (US)",

volume = "16",

pages = "5002",

journal = "Journal of Global Health",

issn = "2047-2978",

publisher = "University of Edinburgh",

}

Tang, X, Ahmed, S, Ahmed, FB, Albrecht, V, Brennsteiner, V, Chang, AL, Chowdhury, NH, Deb, S, Gormley, M, Hasan, T, Kamulaza, L, Khalid, J, Khan, W, Khanam, R, Kshetrapal, P, Luo, H, Maiti, TK, Maitra, A, Mannan, MM, Mueller-Reif, J, Mulenga, C, Nisar, I, Pervin, J, Pokaprakarn, T, Price, J, Qazi, MF, Rittenhouse, K, Sebastiao, Y, Sindano, N, Sinha, T, Sopory, S, Steger, M, Thiruvengadam, R, Wadhwa, N, Xue, L, Aghaeepour, N, Baqui, AH, Bhatnagar, S, Fisher, S, Fox, M, Hampel, D, Kasaro, M, Mann, M, Rahman, A, Sazawal, S, Shenhav, L, Stringer, JS, Zhang, G, Jehan, F & De Paris, K 2026, 'Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes', Journal of Global Health, vol. 16, pp. 5002. https://doi.org/10.7189/jogh.16.05002

TY - JOUR

T1 - Multi-Omics for Mothers and Infants (MOMI) Consortium

T2 - a global initiative to study adverse pregnancy outcomes

AU - Tang, Xin

AU - Ahmed, Salahuddin

AU - Ahmed, Farzana Bashir

AU - Albrecht, Vincent

AU - Brennsteiner, Vincenth

AU - Chang, Alan Lee

AU - Chowdhury, Nabidul Haque

AU - Deb, Saikat

AU - Gormley, Matthew

AU - Hasan, Tarik

AU - Kamulaza, Leah

AU - Khalid, Javairia

AU - Khan, Waqasuddin

AU - Khanam, Rasheda

AU - Kshetrapal, Pallavi

AU - Luo, Hanqi

AU - Maiti, Tushar K.

AU - Maitra, Arindam

AU - Mannan, Mohammad Mohsin

AU - Mueller-Reif, Johannes

AU - Mulenga, Clyde

AU - Nisar, Imran

AU - Pervin, Jesmin

AU - Pokaprakarn, Teeranan

AU - Price, Joni

AU - Qazi, Muhammad F.

AU - Rittenhouse, Katelyn

AU - Sebastiao, Yuri

AU - Sindano, Ntazana

AU - Sinha, Tulika

AU - Sopory, Shailaja

AU - Steger, Medini

AU - Thiruvengadam, Ramachandran

AU - Wadhwa, Nitya

AU - Xue, Lei

AU - Aghaeepour, Nima

AU - Baqui, Abdullah H.

AU - Bhatnagar, Shinjini

AU - Fisher, Susan

AU - Fox, Melissa

AU - Hampel, Daniela

AU - Kasaro, Margaret

AU - Mann, Matthias

AU - Rahman, Anisur

AU - Sazawal, Sunil

AU - Shenhav, Liat

AU - Stringer, Jeffrey Sa

AU - Zhang, Ge

AU - Jehan, Fyezah

AU - De Paris, Kristina

PY - 2026/4/3

Y1 - 2026/4/3

N2 - Background: The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in low- and middle-income countries (LMICs). The MOMI Consortium consists of six different LMIC sites established by The Alliance for Maternal and Newborn Health Improvement in Bangladesh, Pakistan, and Tanzania, the Global Alliance to Prevent Prematurity and Stillbirth in Bangladesh and Zambia, and the Interdisciplinary Group for Advanced Research on Birth Outcomes - DBT India Initiative. It also partners with five analytical partners and three bioinformatic teams. Methods: The combined MOMI cohort includes 24 321 pregnant women, a rich biorepository, and paired socioeconomic and clinical data. Considering the multifactorial aetiologies and molecular drivers of APOs, we applied an integrative multi-omics (genomics, metabolomics, proteomics, nutrient testing) approach to identify site-specific and cohort-wide signatures linked to distinct APOs. Conclusions: This protocol summarises the MOMI study design, sample and data collection methods, data harmonisation, and the various analytics platforms, and discusses potential outcomes for enhanced clinical care and novel diagnostic and therapeutic tools.

AB - Background: The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in low- and middle-income countries (LMICs). The MOMI Consortium consists of six different LMIC sites established by The Alliance for Maternal and Newborn Health Improvement in Bangladesh, Pakistan, and Tanzania, the Global Alliance to Prevent Prematurity and Stillbirth in Bangladesh and Zambia, and the Interdisciplinary Group for Advanced Research on Birth Outcomes - DBT India Initiative. It also partners with five analytical partners and three bioinformatic teams. Methods: The combined MOMI cohort includes 24 321 pregnant women, a rich biorepository, and paired socioeconomic and clinical data. Considering the multifactorial aetiologies and molecular drivers of APOs, we applied an integrative multi-omics (genomics, metabolomics, proteomics, nutrient testing) approach to identify site-specific and cohort-wide signatures linked to distinct APOs. Conclusions: This protocol summarises the MOMI study design, sample and data collection methods, data harmonisation, and the various analytics platforms, and discusses potential outcomes for enhanced clinical care and novel diagnostic and therapeutic tools.

UR - https://www.scopus.com/pages/publications/105034817869

U2 - 10.7189/jogh.16.05002

DO - 10.7189/jogh.16.05002

M3 - Article

C2 - 41926172

AN - SCOPUS:105034817869

SN - 2047-2978

VL - 16

SP - 5002

JO - Journal of Global Health

JF - Journal of Global Health

ER -

Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes

Abstract

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