TY - JOUR
T1 - Multiple micronutrient supplementation during pregnancy in low-income countries
T2 - A meta-analysis of effects on stillbirths and on early and late neonatal mortality
AU - Ronsmans, Carine
AU - Fisher, David J.
AU - Osmond, Clive
AU - Margetts, Barrie M.
AU - Fall, Caroline H.D.
AU - Adou, Pierre
AU - Aguayo, Victor M.
AU - Allen, Lindsay H.
AU - Bhutta, Zulfiqar Ahmed
AU - Christian, Parul
AU - Dang, Shaonong
AU - Desplats, Gwenola
AU - Dibley, Michael
AU - Arifeen, Shams El
AU - Friis, Henrik
AU - Gomo, Exnenia
AU - Haider, Batool Azra
AU - Hidayat, Adi
AU - Jahari, Abbas
AU - Kaes-tel, Pernille
AU - Kolsteren, Patrick
AU - Kusharisupeni,
AU - Mamadoultaibou, Aissa
AU - Manandhar, Dharma Sharna
AU - Margetts, Barrie
AU - Osrin, David
AU - Persson, Lars Ake
AU - Ramakrishnan, Usha
AU - Roberfroid, Domi Nique
AU - Shankar, Anuraj H.
AU - Subarkah,
AU - Sunawang,
AU - Utomo, Budi
AU - Vaidya, Anjana
AU - Yan, Hong
AU - Zagre, Noel
AU - Zeng, Lingxia
PY - 2009/12
Y1 - 2009/12
N2 - Background. Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes Objective. To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials. Methods. Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; lndramayu and Lombok, Indo-nesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women. Results. Supplementation providing approximately 1 RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neo-natal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33). Conclusions. Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.
AB - Background. Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes Objective. To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials. Methods. Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; lndramayu and Lombok, Indo-nesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women. Results. Supplementation providing approximately 1 RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neo-natal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33). Conclusions. Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.
UR - http://www.scopus.com/inward/record.url?scp=76749118585&partnerID=8YFLogxK
U2 - 10.1177/15648265090304s409
DO - 10.1177/15648265090304s409
M3 - Article
AN - SCOPUS:76749118585
SN - 0379-5721
VL - 30
SP - S547-S555
JO - Food and Nutrition Bulletin
JF - Food and Nutrition Bulletin
IS - 4
ER -
