Mycobacterium tuberculosis genotypes in patients developing pulmonary tuberculosis related acute respiratory distress syndrome

Nawal Salahuddin, Mahnaz Tanveer Tanveer, Nisar Ahmed Rao, Saeed Akram, Zahra Hasan, Rumina Hasan

Research output: Contribution to journalArticle

Abstract

Background: Acute Respiratory Distress Syndrome is an uncommon but frequently fatal presentation of pulmonary TB. We attempted to identify whether a specific M. tuberculosis genotype occurs more commonly in patients who develop ARDS.Methods: An observational study carried out at the Aga Khan University Hospital, Karachi, Pakistan enrolled all ARDS patients with tuberculosis. MTB isolates were spoligotyped for strain identification.Results: 725 patients were admitted with pulmonary tuberculosis during the study period. Only 2.5% (18 patients) developed ARDS. Inpatient mortality rate was 58% (7 patients). Genotypes of M. tuberculosis isolates were predominantly CAS I (58.3%) and Unique strains (25%). Beijing and CAS subfamilies were less common; with each genotype identified in 8.3% patients respectively. All except one of the isolated strains were sensitive to usual first line anti-­tubercular drugs.

Original languageUndefined/Unknown
JournalDepartment of Pathology and Laboratory Medicine
DOIs
Publication statusPublished - 1 Nov 2011

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