N-acetyl-β-D-glucosaminidase and inflammatory response after cardiopulmonary bypass

Mohammad Perwaiz Iqbal, Hasanat M. Sharif, Naseema Mehboobali, Farzana A. Yousuf, Abrar H. Khan, Frank W. Sellke

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Objective: To determine the changes in activity of plasma N-acetyl-β-D-glucosaminidase, a marker for inflammation as well as renal, pulmonary and cardiac damage and proinflammatory cytokines in patients undergoing coronary artery bypass grafting and find out the relationship between their plasma levels with clinical outcome of patients. Study Design: Cross-sectional study. Place and Duration of Study: The Aga Khan University, Karachi, from January to June 2003. Patients and Methods: N-Acetyl-β-D-glucosaminidase (NAG) activity and concentrations of tumor necrosis factor-alpha of (TNFα), interleukin 6 (IL-6), interleukin 8 (IL8) and granulocyte-macrophage colony stimulating factor (GM-CSF) were monitored in plasma samples of 12 angina patients undergoing coronary artery bypass grafting (CABG), before, immediately after and 5 days post-surgical procedure. Serum glucose concentrations were also monitored in those patients. Patient's clinical condition was monitored during this time period. Results: No significant increase was observed in plasma NAG activity (a marker of inflammation) or in plasma levels of TNFα, IL-6, IL-8 and GM-CSF immediately after surgery, indicating that cardiopulmonary bypass itself does not produce any significant amount of inflammation immediately after CABG. However, 5 days post surgery, there was a significant increase in plasma NAG activity (p=0.001), TNFα (p=0.047) and GM-CSF (p=0.045). There was no relationship between plasma NAG activity and clinical outcome because various parameters of renal, cardiac and pulmonary functions, though slightly affected, remained within the normal limits. Conclusion: Increased levels of NAG and TNFα did not affect clinical outcome. However, data suggest that NAG can be a potential marker for inflammation and end organ damage following CABG. An increase in GM-CSF on day 5 following CABG indicates enhanced body's defense mechanism against infection.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume18
Issue number2
Publication statusPublished - Feb 2008

Keywords

  • Cardiopulmonary bypass
  • Coronary artery bypass grafting
  • Cytokines
  • Granulocyte-macrophage colony stimulating factor
  • Inflammation
  • N-acetyl-β-D- glucosaminidase
  • Tumor necrosis factor alpha

Fingerprint

Dive into the research topics of 'N-acetyl-β-D-glucosaminidase and inflammatory response after cardiopulmonary bypass'. Together they form a unique fingerprint.

Cite this