Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations

Paul J. Norman; C. V.F. Carrington; M. Byng; L. D. Maxwell; M. D. Curran; H. A.F. Stephens; D. Chandanayingyong; D. H. Verity; K. Hameed; D. D. Ramdath; R. W. Vaughan

doi:10.1038/sj.gene.6363836

Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations

Paul J. Norman, C. V.F. Carrington, M. Byng, L. D. Maxwell, M. D. Curran, H. A.F. Stephens, D. Chandanayingyong, D. H. Verity, K. Hameed, D. D. Ramdath, R. W. Vaughan

Internal Medicine, East Africa

Research output: Contribution to journal › Article › peer-review

157 Citations (Scopus)

Abstract

Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. P_c < 1 × 10^-6) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (P_c < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations.

Original language	English
Pages (from-to)	86-95
Number of pages	10
Journal	Genes and Immunity
Volume	3
Issue number	2
DOIs	https://doi.org/10.1038/sj.gene.6363836
Publication status	Published - Apr 2002

Keywords

African
KIR frequencies
KIR haplotypes
KIR profiles
South Asian

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10.1038/sj.gene.6363836

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Norman, P. J., Carrington, C. V. F., Byng, M., Maxwell, L. D., Curran, M. D., Stephens, H. A. F., Chandanayingyong, D., Verity, D. H., Hameed, K., Ramdath, D. D., & Vaughan, R. W. (2002). Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes and Immunity, 3(2), 86-95. https://doi.org/10.1038/sj.gene.6363836

@article{be2758a6982b437c890b60520c1e8162,

title = "Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations",

abstract = "Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. Pc < 1 × 10-6) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (Pc < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations.",

keywords = "African, KIR frequencies, KIR haplotypes, KIR profiles, South Asian",

author = "Norman, {Paul J.} and Carrington, {C. V.F.} and M. Byng and Maxwell, {L. D.} and Curran, {M. D.} and Stephens, {H. A.F.} and D. Chandanayingyong and Verity, {D. H.} and K. Hameed and Ramdath, {D. D.} and Vaughan, {R. W.}",

note = "Funding Information: We thank the University of West Indies, St Augustine Campus Research and Publications committee and Caribbean Health Research Council for funding the Trinidad sample collection. CVF Carrington{\textquoteright}s visit to Guy{\textquoteright}s Hospital was initially supported by a Rhodes Trust grant. Ethical approval was obtained from the Ethics Committee of the Faculty of Medical Sciences, University of West Indies. Received 4 September 2001, revised 14 November 2001; accepted 19 November 2001",

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doi = "10.1038/sj.gene.6363836",

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T1 - Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations

AU - Norman, Paul J.

AU - Carrington, C. V.F.

AU - Byng, M.

AU - Maxwell, L. D.

AU - Curran, M. D.

AU - Stephens, H. A.F.

AU - Chandanayingyong, D.

AU - Verity, D. H.

AU - Hameed, K.

AU - Ramdath, D. D.

AU - Vaughan, R. W.

N1 - Funding Information: We thank the University of West Indies, St Augustine Campus Research and Publications committee and Caribbean Health Research Council for funding the Trinidad sample collection. CVF Carrington’s visit to Guy’s Hospital was initially supported by a Rhodes Trust grant. Ethical approval was obtained from the Ethics Committee of the Faculty of Medical Sciences, University of West Indies. Received 4 September 2001, revised 14 November 2001; accepted 19 November 2001

PY - 2002/4

Y1 - 2002/4

N2 - Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. Pc < 1 × 10-6) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (Pc < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations.

AB - Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic activity. The number of KIR loci can vary and so a range of genetic profiles is observed. We have determined the KIR genetic profiles from one African (n = 62) and two South Asian (n = 108, n = 78) populations. Several of the KIRs are present at significantly different frequencies between the two major ethnic groups (eg KIR2DS4 gene frequency 0.82 African, 0.47 S Asian. Pc < 1 × 10-6) and this is due to uneven distribution of two KIR haplotype families 'A' and 'B'. All three populations described here displayed a greater degree of diversity of KIR genetic profiles than other populations investigated, which indicates further complexity of underlying haplotypes; in this respect we describe two individuals who appear homozygous for a large deletion including the previously ubiquitous 2DL4. We have also reanalysed three populations that we studied previously, for the presence of a KIR which is now known to be an indicator of the 'B' haplotype. South Asians had the highest overall frequencies of all KIR loci characteristic of 'B' haplotypes (Pc < 0.0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations.

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KW - KIR frequencies

KW - KIR haplotypes

KW - KIR profiles

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SN - 1466-4879

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JO - Genes and Immunity

JF - Genes and Immunity

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ER -

Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations

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Keywords

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