TY - JOUR
T1 - Natural remedies for Alzheimer’s disease
T2 - A systematic review of randomized controlled trials
AU - Ahmad, Saara
AU - Ahmed, Saad Bilal
AU - Khan, Asra
AU - Wasim, Muhammad
AU - Tabassum, Saiqa
AU - Haider, Saida
AU - Ahmed, Fatima
AU - Batool, Zehra
AU - Khaliq, Saima
AU - Rafiq, Hamna
AU - Tikmani, Prashant
AU - Gilani, Anwar ul Hassan
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/1
Y1 - 2023/1
N2 - Alzheimer's disease (AD) is the common type of dementia and is currently incurable. Existing FDA-approved AD drugs may not be effective for everyone, they cannot cure the disease nor stop its progression and their effects diminish over time. Therefore, the present review aimed to explore the role of natural alternatives in the treatment of AD. A systematic search was conducted using Ovid MEDLINE, CINAHL, Cochrane and PubMed databases and reference lists up to November 30, 2021. Only randomized control trials were included and appraised using the National Institute of Health framework. Data analysis showed that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD. Moreover, combination of natural and pharmaceuticals has far better effects than only allopathic treatment. Thus, different herbal remedies in combination with FDA approved drugs are effective and more promising in treatment of AD.
AB - Alzheimer's disease (AD) is the common type of dementia and is currently incurable. Existing FDA-approved AD drugs may not be effective for everyone, they cannot cure the disease nor stop its progression and their effects diminish over time. Therefore, the present review aimed to explore the role of natural alternatives in the treatment of AD. A systematic search was conducted using Ovid MEDLINE, CINAHL, Cochrane and PubMed databases and reference lists up to November 30, 2021. Only randomized control trials were included and appraised using the National Institute of Health framework. Data analysis showed that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD. Moreover, combination of natural and pharmaceuticals has far better effects than only allopathic treatment. Thus, different herbal remedies in combination with FDA approved drugs are effective and more promising in treatment of AD.
KW - Alzheimer's disease
KW - Cognition
KW - Herbs
KW - Randomized clinical trial
UR - https://www.scopus.com/pages/publications/85135833044
U2 - 10.1007/s11011-022-01063-9
DO - 10.1007/s11011-022-01063-9
M3 - Review article
C2 - 35960461
AN - SCOPUS:85135833044
SN - 0885-7490
VL - 38
SP - 17
EP - 44
JO - Metabolic Brain Disease
JF - Metabolic Brain Disease
IS - 1
ER -