Neurodevelopmental outcomes of premature infants at a tertiary care center in Pakistan

Muhammad R. Khan; Prem K. Maheshwari; Huma Shamim; Ali F. Saleem; Shakeel Ahmed; Syed R. Ali; Shahnaz H. Ibrahim

doi:10.1016/j.pediatrneurol.2012.05.010

Neurodevelopmental outcomes of premature infants at a tertiary care center in Pakistan

Muhammad R. Khan, Prem K. Maheshwari, Huma Shamim, Ali F. Saleem, Shakeel Ahmed, Syed R. Ali, Shahnaz H. Ibrahim

Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The low gestational ages and morbidities of premature neonates in neonatal intensive care units exert a significant impact on neurodevelopmental outcomes. This longitudinal cohort study assessed the neurodevelopmental status of premature neonates after discharge from neonatal intensive care units in resource-limited countries such as Pakistan. Developmental assessment involved the Denver Development Screening Test II. One hundred and ten infants discharged from our neonatal intensive care unit completed follow-up at age 6 months. Overall developmental delay was evident in 32% of infants. Birth weight and gestational age exerted significant impacts on development. The mean gestational age of developmentally normal infants was 34 weeks, whereas that of delayed infants was 30.7 weeks (P < 0.01). The mean birth weight of developmentally normal infants was 2.17 kg vs 1.27 kg in delayed infants (P < 0.01). Neonates who developed complications such as respiratory distress syndrome, intraventricular hemorrhage, thrombocytopenia, hypoglycemia, hyponatremia, or hypothermia in neonatal intensive care units proved to be delayed at age 6 months (P < 0.05). Prematurity and its associated complications are linked to adverse neurodevelopmental outcomes.

Original language	English
Pages (from-to)	109-113
Number of pages	5
Journal	Pediatric Neurology
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.pediatrneurol.2012.05.010
Publication status	Published - Aug 2012

Access to Document

10.1016/j.pediatrneurol.2012.05.010

Cite this

@article{119231be31674785a7b22aa97a9d22b6,

title = "Neurodevelopmental outcomes of premature infants at a tertiary care center in Pakistan",

abstract = "The low gestational ages and morbidities of premature neonates in neonatal intensive care units exert a significant impact on neurodevelopmental outcomes. This longitudinal cohort study assessed the neurodevelopmental status of premature neonates after discharge from neonatal intensive care units in resource-limited countries such as Pakistan. Developmental assessment involved the Denver Development Screening Test II. One hundred and ten infants discharged from our neonatal intensive care unit completed follow-up at age 6 months. Overall developmental delay was evident in 32% of infants. Birth weight and gestational age exerted significant impacts on development. The mean gestational age of developmentally normal infants was 34 weeks, whereas that of delayed infants was 30.7 weeks (P < 0.01). The mean birth weight of developmentally normal infants was 2.17 kg vs 1.27 kg in delayed infants (P < 0.01). Neonates who developed complications such as respiratory distress syndrome, intraventricular hemorrhage, thrombocytopenia, hypoglycemia, hyponatremia, or hypothermia in neonatal intensive care units proved to be delayed at age 6 months (P < 0.05). Prematurity and its associated complications are linked to adverse neurodevelopmental outcomes.",

author = "Khan, {Muhammad R.} and Maheshwari, {Prem K.} and Huma Shamim and Saleem, {Ali F.} and Shakeel Ahmed and Ali, {Syed R.} and Ibrahim, {Shahnaz H.}",

note = "Funding Information: Dr. Saleem received research training support from the National Institute of Health's Fogarty International Center (1 D43 TW007585-01). However, the sponsors did not have any role in study design, data collection/analysis, or report writing.",

year = "2012",

month = aug,

doi = "10.1016/j.pediatrneurol.2012.05.010",

language = "English",

volume = "47",

pages = "109--113",

journal = "Pediatric Neurology",

issn = "0887-8994",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Neurodevelopmental outcomes of premature infants at a tertiary care center in Pakistan

AU - Khan, Muhammad R.

AU - Maheshwari, Prem K.

AU - Shamim, Huma

AU - Saleem, Ali F.

AU - Ahmed, Shakeel

AU - Ali, Syed R.

AU - Ibrahim, Shahnaz H.

N1 - Funding Information: Dr. Saleem received research training support from the National Institute of Health's Fogarty International Center (1 D43 TW007585-01). However, the sponsors did not have any role in study design, data collection/analysis, or report writing.

PY - 2012/8

Y1 - 2012/8

N2 - The low gestational ages and morbidities of premature neonates in neonatal intensive care units exert a significant impact on neurodevelopmental outcomes. This longitudinal cohort study assessed the neurodevelopmental status of premature neonates after discharge from neonatal intensive care units in resource-limited countries such as Pakistan. Developmental assessment involved the Denver Development Screening Test II. One hundred and ten infants discharged from our neonatal intensive care unit completed follow-up at age 6 months. Overall developmental delay was evident in 32% of infants. Birth weight and gestational age exerted significant impacts on development. The mean gestational age of developmentally normal infants was 34 weeks, whereas that of delayed infants was 30.7 weeks (P < 0.01). The mean birth weight of developmentally normal infants was 2.17 kg vs 1.27 kg in delayed infants (P < 0.01). Neonates who developed complications such as respiratory distress syndrome, intraventricular hemorrhage, thrombocytopenia, hypoglycemia, hyponatremia, or hypothermia in neonatal intensive care units proved to be delayed at age 6 months (P < 0.05). Prematurity and its associated complications are linked to adverse neurodevelopmental outcomes.

AB - The low gestational ages and morbidities of premature neonates in neonatal intensive care units exert a significant impact on neurodevelopmental outcomes. This longitudinal cohort study assessed the neurodevelopmental status of premature neonates after discharge from neonatal intensive care units in resource-limited countries such as Pakistan. Developmental assessment involved the Denver Development Screening Test II. One hundred and ten infants discharged from our neonatal intensive care unit completed follow-up at age 6 months. Overall developmental delay was evident in 32% of infants. Birth weight and gestational age exerted significant impacts on development. The mean gestational age of developmentally normal infants was 34 weeks, whereas that of delayed infants was 30.7 weeks (P < 0.01). The mean birth weight of developmentally normal infants was 2.17 kg vs 1.27 kg in delayed infants (P < 0.01). Neonates who developed complications such as respiratory distress syndrome, intraventricular hemorrhage, thrombocytopenia, hypoglycemia, hyponatremia, or hypothermia in neonatal intensive care units proved to be delayed at age 6 months (P < 0.05). Prematurity and its associated complications are linked to adverse neurodevelopmental outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84863326503&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2012.05.010

DO - 10.1016/j.pediatrneurol.2012.05.010

M3 - Article

C2 - 22759686

AN - SCOPUS:84863326503

SN - 0887-8994

VL - 47

SP - 109

EP - 113

JO - Pediatric Neurology

JF - Pediatric Neurology

IS - 2

ER -

Neurodevelopmental outcomes of premature infants at a tertiary care center in Pakistan

Abstract

Access to Document

Other files and links

Fingerprint

Cite this