Neurological manifestations of COVID-19

Dureshahwar Kanwar, Abdul Mannan Baig, Mohammad Wasay

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has turned out to be a formidable pandemic. Upcoming evidence from confirmed cases of COVID-19 suggests an anticipated incursion of patients with neurological manifestations in the weeks to come. An expression of the angiotensin-converting enzyme 2 (ACE 2), the cellular receptor for SARS-CoV-2 over the glial cells and neurons have made the brain a potential target. Neurotoxicity may occur as a result of direct, indirect and post-infectious complications. Attention to neurological deficits in COVID-19 is fundamental to ensure appropriate, timely, beneficial management of the affected patients. Most common neurological manifestations seen include dizziness, headache, impaired consciousness, acute cerebrovascular disease, ataxia, and seizures. Anosmia and ageusia have recently been hinted as significant early symptoms in COVID-19. As cases with neurological deficits in COVID-19 emerge, the overall prognosis is yet unknown.

Original languageEnglish
Pages (from-to)S101-S103
JournalJournal of the Pakistan Medical Association
Volume70
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • ACE 2
  • Brain
  • COVID-19
  • Coronavirus
  • Neurotoxicity
  • SARS-CoV-2
  • Seizures

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