TY - JOUR
T1 - Neuropilin-1 (NRP-1) and magnetic nanoparticles, a potential combination for diagnosis and therapy of gliomas
AU - Chen, Lukui
AU - Zhang, Guilong
AU - Shi, Yan
AU - Qiu, Rong
AU - Khan, Ahsan Ali
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly. The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR, PlGF, TGF-β, PDGF, LD22-4 of FGF2, autocrine of HGF/SF, p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas. NRP-1, a multifunctional- receptors protein, would mediate diverse cellular signaling pathways in gliomas, and might potentially act as a novel therapeutic target. In future, magnetic nanoparticles coated with NRP-1 may play a vital role on diagnosis and therapy of gliomas.
AB - In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly. The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR, PlGF, TGF-β, PDGF, LD22-4 of FGF2, autocrine of HGF/SF, p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas. NRP-1, a multifunctional- receptors protein, would mediate diverse cellular signaling pathways in gliomas, and might potentially act as a novel therapeutic target. In future, magnetic nanoparticles coated with NRP-1 may play a vital role on diagnosis and therapy of gliomas.
KW - Gene therapy
KW - Glioma
KW - Glioma stem cell
KW - Magnetic nanoparticle
KW - Neuropilin-1
KW - Trafficking
UR - https://www.scopus.com/pages/publications/84947996332
U2 - 10.2174/1381612821666150917092658
DO - 10.2174/1381612821666150917092658
M3 - Review article
C2 - 26377659
AN - SCOPUS:84947996332
SN - 1381-6128
VL - 21
SP - 5434
EP - 5449
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 37
ER -