Abstract
In this review, Neuropilin-1 (NRP-1) has been focused as a novel molecular target for potential treatment of gliomas. The properties of NRP-1 were described briefly. The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR, PlGF, TGF-β, PDGF, LD22-4 of FGF2, autocrine of HGF/SF, p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas. NRP-1, a multifunctional- receptors protein, would mediate diverse cellular signaling pathways in gliomas, and might potentially act as a novel therapeutic target. In future, magnetic nanoparticles coated with NRP-1 may play a vital role on diagnosis and therapy of gliomas.
| Original language | English (UK) |
|---|---|
| Pages (from-to) | 5434-5449 |
| Number of pages | 16 |
| Journal | Current Pharmaceutical Design |
| Volume | 21 |
| Issue number | 37 |
| DOIs | |
| Publication status | Published - 1 Oct 2015 |
| Externally published | Yes |
Keywords
- Gene therapy
- Glioma
- Glioma stem cell
- Magnetic nanoparticle
- Neuropilin-1
- Trafficking
Fingerprint
Dive into the research topics of 'Neuropilin-1 (NRP-1) and magnetic nanoparticles, a potential combination for diagnosis and therapy of gliomas'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver