Neuropsychological assessment in temporal lobe epilepsy surgery

David Sabsevitz, Karen Blackmon

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Anterior temporal lobectomy (ATL) is an effective treatment for drug-resistant temporal lobe epilepsy, but it is not without risk. Declines in verbal memory and naming abilities following dominant hemisphere ATL are well documented, and declines in visual memory following non-dominant ATL are also reported, although less reliably so. Stereotactic laser interstitial thermal therapy (LITT) is an alternative to surgical resection and is thought to reduce collateral damage to temporal neocortical tissue and in doing so preserve language functions. Assessing risk and identifying those patients at greatest risk for cognitive decline following these interventions are important, and neuropsychological assessment during the pre-surgical stage can provide valuable information toward this goal. Higher preoperative memory and language performance, later age at seizure onset, language dominance in the surgical hemisphere, and larger extent of surgical resection have been found to be strong predictors of cognitive decline following ATL. Although the aim of LITT is to minimize cognitive decline, cognitive outcomes following LITT are not well studied.

Original languageEnglish
Title of host publicationEpilepsy Case Studies
Subtitle of host publicationPearls for Patient Care: Second Edition
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783030590789
ISBN (Print)9783030590772
Publication statusPublished - 19 Dec 2020
Externally publishedYes


  • Ablation
  • Cognition
  • Epilepsy
  • Laser
  • Neuropsychology


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