Neutrophil Function in Chronic Granulocytic Leukaemia before and after Busulphan Treatment

J. A. Whittaker; M. Khurshid; H. R. Hughes

doi:10.1111/j.1365-2141.1974.tb06673.x

Neutrophil Function in Chronic Granulocytic Leukaemia before and after Busulphan Treatment

J. A. Whittaker, M. Khurshid, H. R. Hughes

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Summary. Neutrophil mobilization, phagocytic index (PI) and nitroblue tetrazolium (NBT) dye reduction were reduced in 12 untreated patients with chronic granulocytic leukaemia whilst the serum lysozyme (SL) was increased. After nine patients had been treated with a standard dose of busulphan neutrophil mobilization was normal in six patients and NBT dye reduction normal in all nine patients but although the PI rose towards normal a slight defect which was possibly due to Busulphan therapy remained. The SL fell towards normal in nine patients after treatment but remained significantly different from a control group.

Original language	English
Pages (from-to)	541-550
Number of pages	10
Journal	British Journal of Haematology
Volume	28
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1974.tb06673.x
Publication status	Published - Dec 1974
Externally published	Yes

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10.1111/j.1365-2141.1974.tb06673.x

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abstract = "Summary. Neutrophil mobilization, phagocytic index (PI) and nitroblue tetrazolium (NBT) dye reduction were reduced in 12 untreated patients with chronic granulocytic leukaemia whilst the serum lysozyme (SL) was increased. After nine patients had been treated with a standard dose of busulphan neutrophil mobilization was normal in six patients and NBT dye reduction normal in all nine patients but although the PI rose towards normal a slight defect which was possibly due to Busulphan therapy remained. The SL fell towards normal in nine patients after treatment but remained significantly different from a control group.",

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AB - Summary. Neutrophil mobilization, phagocytic index (PI) and nitroblue tetrazolium (NBT) dye reduction were reduced in 12 untreated patients with chronic granulocytic leukaemia whilst the serum lysozyme (SL) was increased. After nine patients had been treated with a standard dose of busulphan neutrophil mobilization was normal in six patients and NBT dye reduction normal in all nine patients but although the PI rose towards normal a slight defect which was possibly due to Busulphan therapy remained. The SL fell towards normal in nine patients after treatment but remained significantly different from a control group.

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Neutrophil Function in Chronic Granulocytic Leukaemia before and after Busulphan Treatment

Abstract

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