New Botanical Anxiolytics for Use in Companion Animals and Humans

Rui Liu; Fida Ahmed; Christian Cayer; Martha Mullally; Ana Francis Carballo; Marco Otarola Rojas; Mario Garcia; John Baker; Aleksandar Masic; Pablo E. Sanchez; Luis Poveda; Zul Merali; Tony Durst; John T. Arnason

doi:10.1208/s12248-017-0144-y

New Botanical Anxiolytics for Use in Companion Animals and Humans

Rui Liu, Fida Ahmed, Christian Cayer, Martha Mullally, Ana Francis Carballo, Marco Otarola Rojas, Mario Garcia, John Baker, Aleksandar Masic, Pablo E. Sanchez, Luis Poveda, Zul Merali, Tony Durst, John T. Arnason

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen for study as a phytochemical discovery strategy focusing on rare Central American plant families. When orally administered to male Sprague-Dawley rats, the crude plant extract, its ethyl acetate fraction, supercritical carbon dioxide fraction, or its isolated triterpenes reduced anxiety and/or fear-related behavior in standardized behavioral models. Pharmacological studies showed that the extracts acted at the benzodiazepine GABA_A receptor and reduced corticosterone levels. A preparation containing Souroubea fortified with a second triterpene containing plant, Platanus occidentalis, was shown to be safe in a 28-day feeding trial with beagles at 5 times the intended dose. Subsequent trials with beagles in a thunderstorm model of noise aversion showed that the material reduced anxiety behaviors and cortisol levels in dogs. The formulation has been released for the companion animal market in Canada and the USA under the Trademark “Zentrol.” Ongoing research is exploring the use of the material in treatment of anxiety and post-traumatic stress in humans.

Original language	English
Pages (from-to)	1626-1631
Number of pages	6
Journal	AAPS Journal
Volume	19
Issue number	6
DOIs	https://doi.org/10.1208/s12248-017-0144-y
Publication status	Published - 1 Nov 2017
Externally published	Yes

Keywords

GABAA receptor
anxiety
canine noise aversion
elevated plus maize
souroubea

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10.1208/s12248-017-0144-y

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title = "New Botanical Anxiolytics for Use in Companion Animals and Humans",

abstract = "As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen for study as a phytochemical discovery strategy focusing on rare Central American plant families. When orally administered to male Sprague-Dawley rats, the crude plant extract, its ethyl acetate fraction, supercritical carbon dioxide fraction, or its isolated triterpenes reduced anxiety and/or fear-related behavior in standardized behavioral models. Pharmacological studies showed that the extracts acted at the benzodiazepine GABAA receptor and reduced corticosterone levels. A preparation containing Souroubea fortified with a second triterpene containing plant, Platanus occidentalis, was shown to be safe in a 28-day feeding trial with beagles at 5 times the intended dose. Subsequent trials with beagles in a thunderstorm model of noise aversion showed that the material reduced anxiety behaviors and cortisol levels in dogs. The formulation has been released for the companion animal market in Canada and the USA under the Trademark “Zentrol.” Ongoing research is exploring the use of the material in treatment of anxiety and post-traumatic stress in humans.",

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author = "Rui Liu and Fida Ahmed and Christian Cayer and Martha Mullally and Carballo, {Ana Francis} and Rojas, {Marco Otarola} and Mario Garcia and John Baker and Aleksandar Masic and Sanchez, {Pablo E.} and Luis Poveda and Zul Merali and Tony Durst and Arnason, {John T.}",

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AU - Ahmed, Fida

AU - Cayer, Christian

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AU - Rojas, Marco Otarola

AU - Garcia, Mario

AU - Baker, John

AU - Masic, Aleksandar

AU - Sanchez, Pablo E.

AU - Poveda, Luis

AU - Merali, Zul

AU - Durst, Tony

AU - Arnason, John T.

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New Botanical Anxiolytics for Use in Companion Animals and Humans

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Keywords

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