Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

Tafheem Malik; Sheema Hasan; Shahid Pervez; Tasneem Fatima; Darakhshan Jabeen Haleem

doi:10.1007/s11064-016-2073-z

Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem

Department of Pathology and Laboratory Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

Original language	English
Pages (from-to)	3386-3398
Number of pages	13
Journal	Neurochemical Research
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s11064-016-2073-z
Publication status	Published - 1 Dec 2016

Keywords

Astrogliosis
Caudate
Dyskinesia
Glial fibrillary acidic protein
Haloperidol
Nigella sativa oil
Nissl bodies
Nucleus accumbens
Parkinsonism
Rats
Striatum

Access to Document

10.1007/s11064-016-2073-z

Cite this

@article{e8a20b0fa06e488a953a936c90c33f7e,

title = "Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats",

abstract = "The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.",

keywords = "Astrogliosis, Caudate, Dyskinesia, Glial fibrillary acidic protein, Haloperidol, Nigella sativa oil, Nissl bodies, Nucleus accumbens, Parkinsonism, Rats, Striatum",

author = "Tafheem Malik and Sheema Hasan and Shahid Pervez and Tasneem Fatima and Haleem, {Darakhshan Jabeen}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s11064-016-2073-z",

language = "English",

volume = "41",

pages = "3386--3398",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer New York",

number = "12",

}

TY - JOUR

T1 - Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

AU - Malik, Tafheem

AU - Hasan, Sheema

AU - Pervez, Shahid

AU - Fatima, Tasneem

AU - Haleem, Darakhshan Jabeen

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

AB - The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

KW - Astrogliosis

KW - Caudate

KW - Dyskinesia

KW - Glial fibrillary acidic protein

KW - Haloperidol

KW - Nigella sativa oil

KW - Nissl bodies

KW - Nucleus accumbens

KW - Parkinsonism

KW - Rats

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=84991726007&partnerID=8YFLogxK

U2 - 10.1007/s11064-016-2073-z

DO - 10.1007/s11064-016-2073-z

M3 - Article

C2 - 27752803

AN - SCOPUS:84991726007

SN - 0364-3190

VL - 41

SP - 3386

EP - 3398

JO - Neurochemical Research

JF - Neurochemical Research

IS - 12

ER -

Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this