Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

Original languageEnglish
Pages (from-to)3386-3398
Number of pages13
JournalNeurochemical Research
Issue number12
Publication statusPublished - 1 Dec 2016


  • Astrogliosis
  • Caudate
  • Dyskinesia
  • Glial fibrillary acidic protein
  • Haloperidol
  • Nigella sativa oil
  • Nissl bodies
  • Nucleus accumbens
  • Parkinsonism
  • Rats
  • Striatum


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