Non-invasive respiratory support for infants in low- and middle-income countries

Erik A. Jensen, Aasma Chaudhary, Zulfiqar A. Bhutta, Haresh Kirpalani

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The overwhelming majority of neonatal deaths worldwide occur in low- and middle-income countries. Most of these deaths are attributable to respiratory illnesses and complications of preterm birth. The available data suggest that non-invasive continuous positive airway pressure (CPAP) is a safe and cost-effective therapy to reduce neonatal morbidity and mortality in these settings. Bubble CPAP compared to mechanical ventilator-generated CPAP reduces the need for subsequent invasive ventilation in newborn infants. There are limited data on the safety and efficacy of high-flow nasal cannulae in low- and middle-income countries, requiring further study prior to widespread implementation.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalSeminars in Fetal and Neonatal Medicine
Issue number3
Publication statusPublished - 1 Jun 2016


  • Continuous positive airway pressure
  • High-flow nasal cannula
  • Low- and middle-income
  • Low-resource
  • Respiratory distress syndrome


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