Novel Artificial intelligence systems in detecting adenomas in colonoscopy: a systemic review and network meta-analysis.

Sunny Kumar, Mahveer Maheshwari, Shahnoor Aleem, Zoha Batool, Amar Lal, Saifullah Syed, Nida Fatima Daterdiwala, Hina Fatima Memon, Jaweria Azeem, Sajida Moiz Hussain Qamari, Mohammad Jawwad

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Artificial intelligence (AI) has the potential to improve adenoma detection rates (ADRs) during colonoscopy, but the efficacy of various AI-assisted systems remains unclear. Objective: To evaluate and compare the effectiveness of different AI-assisted systems for detecting colorectal neoplasia during colonoscopy. Design: A systematic literature search of PubMed, Scopus, and Google Scholar databases was conducted up to March 4, 2025, to identify randomized controlled trials (RCTs) comparing AI-assisted colonoscopy to conventional colonoscopy. The analysis included AI systems such as GIGenius (Medtronic), CAD-EYE (Fujifilm), Endoangel, Endoscreener, and EndoAID. The primary outcome was adenoma detection rate (ADR), analyzed using random effects models to calculate pooled odds ratios (OR) and 95% confidence intervals (CI). SUCRA rankings and subgroup analyses were also performed. Results: Seventeen RCTs with 10,547 participants were included. EndoAngel showed the highest efficacy (OR 1.84, 95% CI 1.50–2.30; SUCRA 0.9), followed by EndoAID (OR 1.64, 95% CI 1.20–2.26; SUCRA 0.7). CAD-EYE and GI-Genius were similarly ranked (OR 1.46 and 1.45, respectively). Endoscreener was ranked just above the control group (OR 1.37, 95% CI 1.20–1.56; SUCRA 0.4). Conclusion: AI-assisted colonoscopy systems showed improved ADR detection rates compared with traditional colonoscopy.

Original languageEnglish (US)
Article number10.14309/ctg.0000000000000904
JournalClinical and Translational Gastroenterology
DOIs
Publication statusAccepted/In press - 2025
Externally publishedYes

Keywords

  • Artificial intelligence
  • adenoma detection rate
  • colonoscopy
  • colorectal neoplasia

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