Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Sinead Maguire; Samar Al-Emadi; Paula Alba; Mathia Cecilia Aguiar; Talal Al Lawati; Gelsomina Alle; Bonnie Bermas; Suleman Bhana; Anic Branimir; Inita Bulina; Megan Clowse; Karina Cogo; Iris Colunga; Claire Cook; Karen J. Cortez; Kathryn Dao; Milena Gianfrancesco; Monique Gore-Massey; Laure Gossec; Rebecca Grainger; Jonathon Hausman; Tiffany Y.T. Hsu; Kimme Hyrich; Carolina Isnardi; Yumeko Kawano; Rachael Kilding; Daria A. Kusevich; Saskia Lawson-Tovey; Jean Liew; Eoghan Mccarthy; Anna Montgumery; Sebastian Moyano; Noreen Nasir; Ivan Padjen; Charalampos Papagoras; Naomi J. Patel; Mariana Pera; Cecilia Pisoni; Guillermo Pons-Estel; Antonio L. Quiambao; Rosana Quintana; Eric Ruderman; Sebastian Sattui; Veronica Savio; Savino Sciascia; Marieta Sencarova; Rosa Serrano Morales; Faizah Siddique; Emily Sirotich; Jeffrey Sparks; Anja Strangfeld; Paul Sufka; Helen Tanner; Yohana Tissera; Zachary Wallace; Marina L. Werner; Leanna Wise; Angus B. Worthing; Jo Ann Zell; Julija Zepa; Pedro M. Machado; Jinoos Yazdany; Philip Robinson; Richard Conway

doi:10.1093/rheumatology/keac534

Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Sinead Maguire, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, Suleman Bhana, Anic Branimir, Inita Bulina, Megan Clowse, Karina Cogo, Iris Colunga, Claire Cook, Karen J. Cortez, Kathryn Dao, Milena Gianfrancesco, Monique Gore-Massey, Laure Gossec, Rebecca GraingerJonathon Hausman, Tiffany Y.T. Hsu, Kimme Hyrich, Carolina Isnardi, Yumeko Kawano, Rachael Kilding, Daria A. Kusevich, Saskia Lawson-Tovey, Jean Liew, Eoghan Mccarthy, Anna Montgumery, Sebastian Moyano, Noreen Nasir, Ivan Padjen, Charalampos Papagoras, Naomi J. Patel, Mariana Pera, Cecilia Pisoni, Guillermo Pons-Estel, Antonio L. Quiambao, Rosana Quintana, Eric Ruderman, Sebastian Sattui, Veronica Savio, Savino Sciascia, Marieta Sencarova, Rosa Serrano Morales, Faizah Siddique, Emily Sirotich, Jeffrey Sparks, Anja Strangfeld, Paul Sufka, Helen Tanner, Yohana Tissera, Zachary Wallace, Marina L. Werner, Leanna Wise, Angus B. Worthing, Jo Ann Zell, Julija Zepa, Pedro M. Machado, Jinoos Yazdany, Philip Robinson, Richard Conway

Section of Internal Medicine, Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Objective: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. Results: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). Conclusions: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

Original language	English (US)
Pages (from-to)	1621-1626
Number of pages	6
Journal	Rheumatology
Volume	62
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/keac534
Publication status	Published - 1 Apr 2023

Keywords

COVID-19
patient outcomes
pregnancy
rheumatic disease
vaccination
women's health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/rheumatology/keac534

Cite this

Maguire, S., Al-Emadi, S., Alba, P., Aguiar, M. C., Al Lawati, T., Alle, G., Bermas, B., Bhana, S., Branimir, A., Bulina, I., Clowse, M., Cogo, K., Colunga, I., Cook, C., Cortez, K. J., Dao, K., Gianfrancesco, M., Gore-Massey, M., Gossec, L., ... Conway, R. (2023). Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status. Rheumatology, 62(4), 1621-1626. https://doi.org/10.1093/rheumatology/keac534

@article{bed44c820dba43c8a087c27803783dc8,

title = "Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status",

abstract = "Objective: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. Results: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7\% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9\% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3\% (n = 44) of women were unvaccinated, 4.1\% (n = 3) had received one vaccine dose while 35.6\% (n = 26) had two or more doses. Although 83.6\% (n = 61) of women required no treatment for COVID-19, 20.5\% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8\% (n = 3) of unvaccinated women and 3.8\% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5\% (n = 13) vs 18.2\% (n = 2). Conclusions: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.",

keywords = "COVID-19, patient outcomes, pregnancy, rheumatic disease, vaccination, women's health",

author = "Sinead Maguire and Samar Al-Emadi and Paula Alba and Aguiar, \{Mathia Cecilia\} and \{Al Lawati\}, Talal and Gelsomina Alle and Bonnie Bermas and Suleman Bhana and Anic Branimir and Inita Bulina and Megan Clowse and Karina Cogo and Iris Colunga and Claire Cook and Cortez, \{Karen J.\} and Kathryn Dao and Milena Gianfrancesco and Monique Gore-Massey and Laure Gossec and Rebecca Grainger and Jonathon Hausman and Hsu, \{Tiffany Y.T.\} and Kimme Hyrich and Carolina Isnardi and Yumeko Kawano and Rachael Kilding and Kusevich, \{Daria A.\} and Saskia Lawson-Tovey and Jean Liew and Eoghan Mccarthy and Anna Montgumery and Sebastian Moyano and Noreen Nasir and Ivan Padjen and Charalampos Papagoras and Patel, \{Naomi J.\} and Mariana Pera and Cecilia Pisoni and Guillermo Pons-Estel and Quiambao, \{Antonio L.\} and Rosana Quintana and Eric Ruderman and Sebastian Sattui and Veronica Savio and Savino Sciascia and Marieta Sencarova and Morales, \{Rosa Serrano\} and Faizah Siddique and Emily Sirotich and Jeffrey Sparks and Anja Strangfeld and Paul Sufka and Helen Tanner and Yohana Tissera and Zachary Wallace and Werner, \{Marina L.\} and Leanna Wise and Worthing, \{Angus B.\} and Zell, \{Jo Ann\} and Julija Zepa and Machado, \{Pedro M.\} and Jinoos Yazdany and Philip Robinson and Richard Conway",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology.",

year = "2023",

month = apr,

day = "1",

doi = "10.1093/rheumatology/keac534",

language = "English (US)",

volume = "62",

pages = "1621--1626",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "4",

}

Maguire, S, Al-Emadi, S, Alba, P, Aguiar, MC, Al Lawati, T, Alle, G, Bermas, B, Bhana, S, Branimir, A, Bulina, I, Clowse, M, Cogo, K, Colunga, I, Cook, C, Cortez, KJ, Dao, K, Gianfrancesco, M, Gore-Massey, M, Gossec, L, Grainger, R, Hausman, J, Hsu, TYT, Hyrich, K, Isnardi, C, Kawano, Y, Kilding, R, Kusevich, DA, Lawson-Tovey, S, Liew, J, Mccarthy, E, Montgumery, A, Moyano, S, Nasir, N, Padjen, I, Papagoras, C, Patel, NJ, Pera, M, Pisoni, C, Pons-Estel, G, Quiambao, AL, Quintana, R, Ruderman, E, Sattui, S, Savio, V, Sciascia, S, Sencarova, M, Morales, RS, Siddique, F, Sirotich, E, Sparks, J, Strangfeld, A, Sufka, P, Tanner, H, Tissera, Y, Wallace, Z, Werner, ML, Wise, L, Worthing, AB, Zell, JA, Zepa, J, Machado, PM, Yazdany, J, Robinson, P & Conway, R 2023, 'Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status', Rheumatology, vol. 62, no. 4, pp. 1621-1626. https://doi.org/10.1093/rheumatology/keac534

TY - JOUR

T1 - Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

AU - Maguire, Sinead

AU - Al-Emadi, Samar

AU - Alba, Paula

AU - Aguiar, Mathia Cecilia

AU - Al Lawati, Talal

AU - Alle, Gelsomina

AU - Bermas, Bonnie

AU - Bhana, Suleman

AU - Branimir, Anic

AU - Bulina, Inita

AU - Clowse, Megan

AU - Cogo, Karina

AU - Colunga, Iris

AU - Cook, Claire

AU - Cortez, Karen J.

AU - Dao, Kathryn

AU - Gianfrancesco, Milena

AU - Gore-Massey, Monique

AU - Gossec, Laure

AU - Grainger, Rebecca

AU - Hausman, Jonathon

AU - Hsu, Tiffany Y.T.

AU - Hyrich, Kimme

AU - Isnardi, Carolina

AU - Kawano, Yumeko

AU - Kilding, Rachael

AU - Kusevich, Daria A.

AU - Lawson-Tovey, Saskia

AU - Liew, Jean

AU - Mccarthy, Eoghan

AU - Montgumery, Anna

AU - Moyano, Sebastian

AU - Nasir, Noreen

AU - Padjen, Ivan

AU - Papagoras, Charalampos

AU - Patel, Naomi J.

AU - Pera, Mariana

AU - Pisoni, Cecilia

AU - Pons-Estel, Guillermo

AU - Quiambao, Antonio L.

AU - Quintana, Rosana

AU - Ruderman, Eric

AU - Sattui, Sebastian

AU - Savio, Veronica

AU - Sciascia, Savino

AU - Sencarova, Marieta

AU - Morales, Rosa Serrano

AU - Siddique, Faizah

AU - Sirotich, Emily

AU - Sparks, Jeffrey

AU - Strangfeld, Anja

AU - Sufka, Paul

AU - Tanner, Helen

AU - Tissera, Yohana

AU - Wallace, Zachary

AU - Werner, Marina L.

AU - Wise, Leanna

AU - Worthing, Angus B.

AU - Zell, Jo Ann

AU - Zepa, Julija

AU - Machado, Pedro M.

AU - Yazdany, Jinoos

AU - Robinson, Philip

AU - Conway, Richard

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Objective: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. Results: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). Conclusions: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

AB - Objective: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. Results: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). Conclusions: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

KW - COVID-19

KW - patient outcomes

KW - pregnancy

KW - rheumatic disease

KW - vaccination

KW - women's health

UR - https://www.scopus.com/pages/publications/85145283788

U2 - 10.1093/rheumatology/keac534

DO - 10.1093/rheumatology/keac534

M3 - Article

C2 - 36124987

AN - SCOPUS:85145283788

SN - 1462-0324

VL - 62

SP - 1621

EP - 1626

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Abstract

Keywords

UN SDGs

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