Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera: A Case Report

Mohammad S. Afana; Mohammad Abu-Tineh; Awni Alshurafa; Khalid Ahmed; Mohammed Abdulgayoom; Mohamed A. Yassin

doi:10.1159/000535742

Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera: A Case Report

Mohammad S. Afana, Mohammad Abu-Tineh, Awni Alshurafa, Khalid Ahmed, Mohammed Abdulgayoom, Mohamed A. Yassin

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Polycythemia vera (PV) is one of the myeloproliferative neoplasms (MPN) diagnosed by World Health Organization (WHO) criteria 2016, which requires the presence of 3 major criteria: high hemoglobin/hematocrit, bone marrow findings, and Janus Kinase 2 (JAK2) mutation or two major and one minor criteria, including erythropoietin (EPO) level. However, in clinical practice, difficulties in diagnosis can arise as it may be masked by secondary causes for erythrocytosis such as smoking or obstructive sleep apnea (OSA). Case Presentation: Here, we report a 55-year-old gentleman, morbidly obese with OSA on home continuous positive airway pressure (CPAP) machine, who was incidentally found to have polycythemia. Further evaluation confirmed the diagnosis of PV. Conclusion: PV can be masked by the assumption of secondary polycythemia based on history. This underscores the importance of screening such cohort through JAK2 and EPO testing to avoid missing PV.

Original language	English (US)
Pages (from-to)	91-95
Number of pages	5
Journal	Case Reports in Oncology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1159/000535742
Publication status	Published - 11 Jan 2024
Externally published	Yes

Keywords

Janus Kinase 2 mutation
Myeloproliferative neoplasm
Polycythemia vera
Secondary polycythemia
Sleep apnea

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10.1159/000535742

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@article{52b590446e7b40e7bed1f7451d5c66e4,

title = "Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera: A Case Report",

abstract = "Introduction: Polycythemia vera (PV) is one of the myeloproliferative neoplasms (MPN) diagnosed by World Health Organization (WHO) criteria 2016, which requires the presence of 3 major criteria: high hemoglobin/hematocrit, bone marrow findings, and Janus Kinase 2 (JAK2) mutation or two major and one minor criteria, including erythropoietin (EPO) level. However, in clinical practice, difficulties in diagnosis can arise as it may be masked by secondary causes for erythrocytosis such as smoking or obstructive sleep apnea (OSA). Case Presentation: Here, we report a 55-year-old gentleman, morbidly obese with OSA on home continuous positive airway pressure (CPAP) machine, who was incidentally found to have polycythemia. Further evaluation confirmed the diagnosis of PV. Conclusion: PV can be masked by the assumption of secondary polycythemia based on history. This underscores the importance of screening such cohort through JAK2 and EPO testing to avoid missing PV.",

keywords = "Janus Kinase 2 mutation, Myeloproliferative neoplasm, Polycythemia vera, Secondary polycythemia, Sleep apnea",

author = "Afana, \{Mohammad S.\} and Mohammad Abu-Tineh and Awni Alshurafa and Khalid Ahmed and Mohammed Abdulgayoom and Yassin, \{Mohamed A.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by S. Karger AG, Basel.",

year = "2024",

month = jan,

day = "11",

doi = "10.1159/000535742",

language = "English (US)",

volume = "17",

pages = "91--95",

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T1 - Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera

T2 - A Case Report

AU - Afana, Mohammad S.

AU - Abu-Tineh, Mohammad

AU - Alshurafa, Awni

AU - Ahmed, Khalid

AU - Abdulgayoom, Mohammed

AU - Yassin, Mohamed A.

PY - 2024/1/11

Y1 - 2024/1/11

N2 - Introduction: Polycythemia vera (PV) is one of the myeloproliferative neoplasms (MPN) diagnosed by World Health Organization (WHO) criteria 2016, which requires the presence of 3 major criteria: high hemoglobin/hematocrit, bone marrow findings, and Janus Kinase 2 (JAK2) mutation or two major and one minor criteria, including erythropoietin (EPO) level. However, in clinical practice, difficulties in diagnosis can arise as it may be masked by secondary causes for erythrocytosis such as smoking or obstructive sleep apnea (OSA). Case Presentation: Here, we report a 55-year-old gentleman, morbidly obese with OSA on home continuous positive airway pressure (CPAP) machine, who was incidentally found to have polycythemia. Further evaluation confirmed the diagnosis of PV. Conclusion: PV can be masked by the assumption of secondary polycythemia based on history. This underscores the importance of screening such cohort through JAK2 and EPO testing to avoid missing PV.

AB - Introduction: Polycythemia vera (PV) is one of the myeloproliferative neoplasms (MPN) diagnosed by World Health Organization (WHO) criteria 2016, which requires the presence of 3 major criteria: high hemoglobin/hematocrit, bone marrow findings, and Janus Kinase 2 (JAK2) mutation or two major and one minor criteria, including erythropoietin (EPO) level. However, in clinical practice, difficulties in diagnosis can arise as it may be masked by secondary causes for erythrocytosis such as smoking or obstructive sleep apnea (OSA). Case Presentation: Here, we report a 55-year-old gentleman, morbidly obese with OSA on home continuous positive airway pressure (CPAP) machine, who was incidentally found to have polycythemia. Further evaluation confirmed the diagnosis of PV. Conclusion: PV can be masked by the assumption of secondary polycythemia based on history. This underscores the importance of screening such cohort through JAK2 and EPO testing to avoid missing PV.

KW - Janus Kinase 2 mutation

KW - Myeloproliferative neoplasm

KW - Polycythemia vera

KW - Secondary polycythemia

KW - Sleep apnea

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DO - 10.1159/000535742

M3 - Article

AN - SCOPUS:85182913935

SN - 1662-6575

VL - 17

SP - 91

EP - 95

JO - Case Reports in Oncology

JF - Case Reports in Oncology

IS - 1

ER -

Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera: A Case Report

Abstract

Keywords

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