Ocular manifestation, complications and aetiological factors in Stevens-Johnson syndrome/toxic epidermal necrolysis

Shaukat Ali Chhipa; Sadia Masood; Yasir Salarzai; Qazi Assad Khan; Khabir Ahmad; Sara Sajid

Ocular manifestation, complications and aetiological factors in Stevens-Johnson syndrome/toxic epidermal necrolysis

Shaukat Ali Chhipa, Sadia Masood, Yasir Salarzai, Qazi Assad Khan, Khabir Ahmad, Sara Sajid

Department of Medicine, Medical College, Pakistan

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Abstract

OBJECTIVE:

To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital.

METHODS:

The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/ToxicEpidermal Necrosis between January 2000 and December 2011. SPSS 19 was used for statistical analysis.

RESULTS:

There were 87 patients; 48(55.2%) of them being males.The overall mean age was 33.2±22.2 years, ranging from 1 month to 84 years. The most common aetiology was idiopathic 20(23%) followed by non-steroidal inflammatory drugs and anti-epileptics 11(12.6%) each. Besides, 84(96.6%) patients had oral mucosal involvement whereas 45(51.7%) had ocular and 27(31.0%) had genital-mucosal involvement. Glassroding was performed in 16(18.4%) patients due to minor conjunctival adhesions.

CONCLUSION:

Ocular manifestations of varying severity were frequent, with drugs being the most common aetiology

Original language	Undefined/Unknown
Journal	Department of Surgery
Publication status	Published - 1 Jan 2015

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Ocular manifestation complications and aetiological factors in S

http://ecommons.aku.edu/pakistan_fhs_mc_surg_surg/348

Cite this

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title = "Ocular manifestation, complications and aetiological factors in Stevens-Johnson syndrome/toxic epidermal necrolysis",

abstract = "Abstract OBJECTIVE: To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital. METHODS: The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/ToxicEpidermal Necrosis between January 2000 and December 2011. SPSS 19 was used for statistical analysis. RESULTS: There were 87 patients; 48(55.2\%) of them being males.The overall mean age was 33.2±22.2 years, ranging from 1 month to 84 years. The most common aetiology was idiopathic 20(23\%) followed by non-steroidal inflammatory drugs and anti-epileptics 11(12.6\%) each. Besides, 84(96.6\%) patients had oral mucosal involvement whereas 45(51.7\%) had ocular and 27(31.0\%) had genital-mucosal involvement. Glassroding was performed in 16(18.4\%) patients due to minor conjunctival adhesions. CONCLUSION: Ocular manifestations of varying severity were frequent, with drugs being the most common aetiology",

author = "Chhipa, \{Shaukat Ali\} and Sadia Masood and Yasir Salarzai and Khan, \{Qazi Assad\} and Khabir Ahmad and Sara Sajid",

year = "2015",

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language = "Undefined/Unknown",

journal = "Department of Surgery",

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TY - JOUR

T1 - Ocular manifestation, complications and aetiological factors in Stevens-Johnson syndrome/toxic epidermal necrolysis

AU - Chhipa, Shaukat Ali

AU - Masood, Sadia

AU - Salarzai, Yasir

AU - Khan, Qazi Assad

AU - Ahmad, Khabir

AU - Sajid, Sara

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Abstract OBJECTIVE: To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital. METHODS: The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/ToxicEpidermal Necrosis between January 2000 and December 2011. SPSS 19 was used for statistical analysis. RESULTS: There were 87 patients; 48(55.2%) of them being males.The overall mean age was 33.2±22.2 years, ranging from 1 month to 84 years. The most common aetiology was idiopathic 20(23%) followed by non-steroidal inflammatory drugs and anti-epileptics 11(12.6%) each. Besides, 84(96.6%) patients had oral mucosal involvement whereas 45(51.7%) had ocular and 27(31.0%) had genital-mucosal involvement. Glassroding was performed in 16(18.4%) patients due to minor conjunctival adhesions. CONCLUSION: Ocular manifestations of varying severity were frequent, with drugs being the most common aetiology

AB - Abstract OBJECTIVE: To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital. METHODS: The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/ToxicEpidermal Necrosis between January 2000 and December 2011. SPSS 19 was used for statistical analysis. RESULTS: There were 87 patients; 48(55.2%) of them being males.The overall mean age was 33.2±22.2 years, ranging from 1 month to 84 years. The most common aetiology was idiopathic 20(23%) followed by non-steroidal inflammatory drugs and anti-epileptics 11(12.6%) each. Besides, 84(96.6%) patients had oral mucosal involvement whereas 45(51.7%) had ocular and 27(31.0%) had genital-mucosal involvement. Glassroding was performed in 16(18.4%) patients due to minor conjunctival adhesions. CONCLUSION: Ocular manifestations of varying severity were frequent, with drugs being the most common aetiology

M3 - Article

JO - Department of Surgery

JF - Department of Surgery

ER -