Optimization of a noncanonical anti-infective: Interrogation of the target binding pocket for a small-molecule inhibitor of Escherichia coli polysaccharide capsule expression

Biochemistry, Genetics and Molecular Biology

• Polysaccharide 100%
• Small Molecule 100%
• Binding Site 100%
• Escherichia coli 100%
• Dynamics 50%
• Conformation 50%
• Conformational Change 50%
• Transcriptional Repressor 50%
• Hydrogen/Deuterium Exchange Mass Spectrometry 50%
• DNA-binding Domain 50%
• Biogenesis 50%
• Antibiotic Resistance 50%

Immunology and Microbiology

• Escherichia coli 100%
• Binding Site 100%
• Conformational Transition 50%
• Repressor Gene 50%
• Dynamics 50%
• Biogenesis 50%
• Conformation 50%
• DNA Binding 50%
• Hydrogen/Deuterium Exchange Mass Spectrometry 50%
• Antimicrobial Resistance 50%
• Peptides 50%