Optimization of Ibuprofen Therapeutic System for Enhanced Transdermal Delivery: A Quality by Design Approach

Muhammad Naeem; Taniya Iqbal; Zarqa Nawaz; Sajjad Hussain; Arslan Ahmer; Hetesh Kumar; Muhammad Yousuf; Irfan Irshad; Ali Ahmad; Om Parkash

Optimization of Ibuprofen Therapeutic System for Enhanced Transdermal Delivery: A Quality by Design Approach

Muhammad Naeem, Taniya Iqbal, Zarqa Nawaz, Sajjad Hussain, Arslan Ahmer, Hetesh Kumar, Muhammad Yousuf, Irfan Irshad, Ali Ahmad, Om Parkash

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The purpose of present study was to develop and evaluate microemulsion based gel (MEBG) formulation for transdermal delivery of a poorly, water soluble drug ibuprofen. Pseudoternary phase dia-grams were developed for microemulsions composed of oil (oleic acid), Smix (Labrasol and ethanol) and water. Microemulsion was optimized using Box Behnken design (BBD), the independent variables selected were oil, Smix and water; dependent variables were cumulative amount permeated across Rabbit skin in 24 h (Q₂₄), flux, and lag time. Optimized microemulsion of ibuprofen was added to gel base of carbomer 940 to formulate MEBG. It was found stable and safe after subjected to stability and skin irritation stud-ies, respectively. It showed significant skin permeation and %inhibition of edema when compared with control gel. MEBG of ibuprofen was formulated and optimized using BBD and could provide an effective treatment in the management of rheumatoid arthritis.

Original language	English (UK)
Pages (from-to)	2241-2249
Number of pages	9
Journal	Latin American Journal of Pharmacy
Volume	39
Issue number	11
Publication status	Published - 2020
Externally published	Yes

Keywords

Anti-inflammatory study
BBD
Ibuprofen
In vitro study
MEBG

Cite this

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title = "Optimization of Ibuprofen Therapeutic System for Enhanced Transdermal Delivery: A Quality by Design Approach",

abstract = "The purpose of present study was to develop and evaluate microemulsion based gel (MEBG) formulation for transdermal delivery of a poorly, water soluble drug ibuprofen. Pseudoternary phase dia-grams were developed for microemulsions composed of oil (oleic acid), Smix (Labrasol and ethanol) and water. Microemulsion was optimized using Box Behnken design (BBD), the independent variables selected were oil, Smix and water; dependent variables were cumulative amount permeated across Rabbit skin in 24 h (Q24), flux, and lag time. Optimized microemulsion of ibuprofen was added to gel base of carbomer 940 to formulate MEBG. It was found stable and safe after subjected to stability and skin irritation stud-ies, respectively. It showed significant skin permeation and \%inhibition of edema when compared with control gel. MEBG of ibuprofen was formulated and optimized using BBD and could provide an effective treatment in the management of rheumatoid arthritis.",

keywords = "Anti-inflammatory study, BBD, Ibuprofen, In vitro study, MEBG",

author = "Muhammad Naeem and Taniya Iqbal and Zarqa Nawaz and Sajjad Hussain and Arslan Ahmer and Hetesh Kumar and Muhammad Yousuf and Irfan Irshad and Ali Ahmad and Om Parkash",

year = "2020",

language = "English (UK)",

volume = "39",

pages = "2241--2249",

journal = "Latin American Journal of Pharmacy",

issn = "0326-2383",

publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",

number = "11",

}

TY - JOUR

T1 - Optimization of Ibuprofen Therapeutic System for Enhanced Transdermal Delivery

T2 - A Quality by Design Approach

AU - Naeem, Muhammad

AU - Iqbal, Taniya

AU - Nawaz, Zarqa

AU - Hussain, Sajjad

AU - Ahmer, Arslan

AU - Kumar, Hetesh

AU - Yousuf, Muhammad

AU - Irshad, Irfan

AU - Ahmad, Ali

AU - Parkash, Om

PY - 2020

Y1 - 2020

N2 - The purpose of present study was to develop and evaluate microemulsion based gel (MEBG) formulation for transdermal delivery of a poorly, water soluble drug ibuprofen. Pseudoternary phase dia-grams were developed for microemulsions composed of oil (oleic acid), Smix (Labrasol and ethanol) and water. Microemulsion was optimized using Box Behnken design (BBD), the independent variables selected were oil, Smix and water; dependent variables were cumulative amount permeated across Rabbit skin in 24 h (Q24), flux, and lag time. Optimized microemulsion of ibuprofen was added to gel base of carbomer 940 to formulate MEBG. It was found stable and safe after subjected to stability and skin irritation stud-ies, respectively. It showed significant skin permeation and %inhibition of edema when compared with control gel. MEBG of ibuprofen was formulated and optimized using BBD and could provide an effective treatment in the management of rheumatoid arthritis.

AB - The purpose of present study was to develop and evaluate microemulsion based gel (MEBG) formulation for transdermal delivery of a poorly, water soluble drug ibuprofen. Pseudoternary phase dia-grams were developed for microemulsions composed of oil (oleic acid), Smix (Labrasol and ethanol) and water. Microemulsion was optimized using Box Behnken design (BBD), the independent variables selected were oil, Smix and water; dependent variables were cumulative amount permeated across Rabbit skin in 24 h (Q24), flux, and lag time. Optimized microemulsion of ibuprofen was added to gel base of carbomer 940 to formulate MEBG. It was found stable and safe after subjected to stability and skin irritation stud-ies, respectively. It showed significant skin permeation and %inhibition of edema when compared with control gel. MEBG of ibuprofen was formulated and optimized using BBD and could provide an effective treatment in the management of rheumatoid arthritis.

KW - Anti-inflammatory study

KW - BBD

KW - Ibuprofen

KW - In vitro study

KW - MEBG

UR - https://www.scopus.com/pages/publications/85096111405

M3 - Article

AN - SCOPUS:85096111405

SN - 0326-2383

VL - 39

SP - 2241

EP - 2249

JO - Latin American Journal of Pharmacy

JF - Latin American Journal of Pharmacy

IS - 11

ER -

Optimization of Ibuprofen Therapeutic System for Enhanced Transdermal Delivery: A Quality by Design Approach

Abstract

Keywords

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