Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure

Natasha Bahadur Ali; Hayat Ullah; Mohammad Usman Shaikh; Salman Adil

Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure

Natasha Bahadur Ali, Hayat Ullah, Mohammad Usman Shaikh, Salman Adil

Research output: Contribution to journal › Article

Abstract

Aim: We determined the frequency of graft-versus-host disease (GvHD) and overall survival (OS) in sex matched vs mismatched transplant.Methods: Medical records were analyzed of patients undergoing transplant from 2004 to 2016. Variables included age, sex of patient and donor, indication, conditioning regimen, stem cell source, frequency of GvHD and OS.Results: We performed n = 162 allogeneic stem cell transplants. The most common conditioning regimen was busulfan/cyclophosphamide (n = 64). There was no difference in the frequency of GvHD in both groups. The transplant related mortality was higher (8.7%) in sex-mismatched transplants. The OS in both groups was similar.Conclusion: Our study showed higher transplant-related mortality in sex-mismatched transplant. There was no difference in GvHD and OS in both groups.

Original language	Undefined/Unknown
Journal	Section of Haematology/Oncology
Publication status	Published - 18 Dec 2019

Access to Document

http://ecommons.aku.edu/pakistan_fhs_mc_med_haematol_oncol/59

Cite this

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title = "Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure",

abstract = "Aim: We determined the frequency of graft-versus-host disease (GvHD) and overall survival (OS) in sex matched vs mismatched transplant.Methods: Medical records were analyzed of patients undergoing transplant from 2004 to 2016. Variables included age, sex of patient and donor, indication, conditioning regimen, stem cell source, frequency of GvHD and OS.Results: We performed n = 162 allogeneic stem cell transplants. The most common conditioning regimen was busulfan/cyclophosphamide (n = 64). There was no difference in the frequency of GvHD in both groups. The transplant related mortality was higher (8.7%) in sex-mismatched transplants. The OS in both groups was similar.Conclusion: Our study showed higher transplant-related mortality in sex-mismatched transplant. There was no difference in GvHD and OS in both groups.",

author = "Ali, {Natasha Bahadur} and Hayat Ullah and Shaikh, {Mohammad Usman} and Salman Adil",

year = "2019",

month = dec,

day = "18",

language = "Undefined/Unknown",

journal = "Section of Haematology/Oncology",

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T1 - Outcome of donor and recipient sex match versus mismatch in stem cell transplant procedure

AU - Ali, Natasha Bahadur

AU - Ullah, Hayat

AU - Shaikh, Mohammad Usman

AU - Adil, Salman

PY - 2019/12/18

Y1 - 2019/12/18

N2 - Aim: We determined the frequency of graft-versus-host disease (GvHD) and overall survival (OS) in sex matched vs mismatched transplant.Methods: Medical records were analyzed of patients undergoing transplant from 2004 to 2016. Variables included age, sex of patient and donor, indication, conditioning regimen, stem cell source, frequency of GvHD and OS.Results: We performed n = 162 allogeneic stem cell transplants. The most common conditioning regimen was busulfan/cyclophosphamide (n = 64). There was no difference in the frequency of GvHD in both groups. The transplant related mortality was higher (8.7%) in sex-mismatched transplants. The OS in both groups was similar.Conclusion: Our study showed higher transplant-related mortality in sex-mismatched transplant. There was no difference in GvHD and OS in both groups.

AB - Aim: We determined the frequency of graft-versus-host disease (GvHD) and overall survival (OS) in sex matched vs mismatched transplant.Methods: Medical records were analyzed of patients undergoing transplant from 2004 to 2016. Variables included age, sex of patient and donor, indication, conditioning regimen, stem cell source, frequency of GvHD and OS.Results: We performed n = 162 allogeneic stem cell transplants. The most common conditioning regimen was busulfan/cyclophosphamide (n = 64). There was no difference in the frequency of GvHD in both groups. The transplant related mortality was higher (8.7%) in sex-mismatched transplants. The OS in both groups was similar.Conclusion: Our study showed higher transplant-related mortality in sex-mismatched transplant. There was no difference in GvHD and OS in both groups.

M3 - Article

JO - Section of Haematology/Oncology

JF - Section of Haematology/Oncology

ER -