Outcome of endoscopic therapeutic interventions: are they different among various non-malignant esophageal diseases.

Rustam Khan, Shahab Abid, Saeed Hamid, Zaigham Abbas, Hasnain Shah, Wasim Jafri

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


BACKGROUND: This study was carried out to evaluate and compare the outcome of various causes of non-malignant lesions of the esophagus after endoscopic therapeutic intervention. METHODS: A cohort of patients with non-malignant dysphagia presenting at Aga Khan University hospital, a tertiary care setting who underwent endoscopic intervention was studied. Response to treatment was evaluated by improvement in dysphagia score on a scale of 0-4 and weight gain. RESULTS: 99 subjects (53 males) were included. Mean age was 48.6 +/- 17.2 years. Dysphagia for solids was present in 48%, for liquids in 3% and for both in 49% patients. Significant weight loss (>10% body weight) occurred in 35 (35.3%) patients. Achalasia was diagnosed in 49.5%, peptic stricture in 30.4%, post sclerotherapy stricture in 12.1%, corrosive injury in 4%, post-operative stricture in 4%. In comparative analysis of achalasia and inflammatory groups, good response to dysphagia was seen in 40/49 (82%) and 22/50 (44%) respectively p < 0.001. Weight gain was 35/49 (72%) and 22/50 (44%) p <0.001 respectively. Significantly, more endoscopic sessions were required in inflammatory group compare to achalasia; 2.2 and 1.1 respectively; p <0.001 and 160% complications rate in inflammatory group comparing to no complications in achalasia. CONCLUSIONS: Dysphagia and weight loss were common presentations in non-malignant esophageal diseases. Therapeutic intervention in inflammatory group was associated with high complication than the achalasia group.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalJournal of Ayub Medical College, Abbottabad : JAMC
Issue number4
Publication statusPublished - 2005


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