Outcome of pediatric patients with lymphoma following stem cell transplant: A single institution report

Hassan Sumaili, Amani Al-Kofide, Amal Al-Seraihi, Mouhab Ayas, Khawar Siddiqui, Hassan El-Solh, Abdallah Al-Jefri, Ali Al-Ahmari, Amal Mohamed, Mohammed Anas, Asim F. Belgaumi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Hematopoietic stem cell transplant (HSCT) is recommended for pediatric patients with relapsed/refractory lymphoma even though the evidence for this is limited. We retrospectively reviewed records of 57 patients (29 Hodgkin lymphoma [HL], 28 non-Hodgkin lymphoma [NHL]) who underwent HSCT between 1995 and 2012. All demonstrated chemoresponsiveness prior to HSCT and 44 patients had a complete response. All underwent myeloablative conditioning, 38 chemotherapy-based and 19 total body irradiation-based. Forty-one patients received autologous and 16 allogeneic HSCT. Twelve (21%) died within 100 days post-HSCT, and 25 patients relapsed at a median of 1.6 months post-HSCT. Three patients developed second malignant neoplasms. Five-year overall survival (OS) was 50.5% and event-free survival (EFS) was 43.4%. Outcomes for HL were significantly better than those for NHL (OS 61.9% vs. 38.7% [p = 0.005] and EFS 60.4% vs. 26% [p = 0.008]). In summary, approximately half of all pediatric patients with lymphoma who failed first-line therapy and demonstrated chemosensitivity to second-line therapy can be salvaged with HSCT.

Original languageEnglish
Pages (from-to)1327-1334
Number of pages8
JournalLeukemia and Lymphoma
Issue number5
Publication statusPublished - 1 May 2015
Externally publishedYes


  • Lymphoma
  • Outcome
  • Pediatrics
  • Stem cell transplant


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