Abstract
Oxidative stress (OS) occurs on account of the disproportion of pro and antioxidants mainly due to insufficient production or nonavailability of endogenous and exogenous antioxidants in the body. Several biomarkers of OS have been identified in normally cycling human ovaries, indicating the existence of a subtle equilibrium between reactive oxygen species (ROS) and antioxidant enzymes. Elevated levels of ROS can disturb the endometrium and uterus lining and impair embryo implantation, leading to reduced fertility. ROS can hurt the reproductive tract, including the fallopian tubes and the cervix, which can interfere with fertilization and implantation. Overall, OS can have a significant impact on female fertility by impairing oocyte and ovarian function, interfering with embryo implantation, and causing inflammation and tissue damage in the reproductive system. This chapter aims to discuss OS initiating disturbance in female reproductive processes leading to failure of implantation and reproductive disorders and outlines a few pregnancy complications, which may cause secondary infertility.
| Original language | English |
|---|---|
| Title of host publication | Fundamental Principles of Oxidative Stress in Metabolism and Reproduction |
| Subtitle of host publication | Prevention and Management |
| Publisher | Elsevier |
| Pages | 185-200 |
| Number of pages | 16 |
| ISBN (Electronic) | 9780443188077 |
| ISBN (Print) | 9780443188060 |
| DOIs | |
| Publication status | Published - 1 Jan 2024 |
Keywords
- Cellular physiology
- Female reproduction
- Oxidative stress
- Physiology
- Reproductive
- Subfertility