Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

A. Javaid, R. Hasan, A. Zafar, M. A. Chaudry, S. Qayyum, E. Qadeer, Z. Shaheen, N. Agha, N. Rizvi, M. Z. Afridi, M. K. Chima, A. R. Khan, A. Ghafoor, S. Khan, S. R. Awan, S. Akhtar, K. Choudry, Z. H. Iqbal, M. Ansarie, N. Ahmad

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Drug resistance
  • Pakistan
  • Retreatment cases

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