Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

A. Javaid; R. Hasan; A. Zafar; M. A. Chaudry; S. Qayyum; E. Qadeer; Z. Shaheen; N. Agha; N. Rizvi; M. Z. Afridi; M. K. Chima; A. R. Khan; A. Ghafoor; S. Khan; S. R. Awan; S. Akhtar; K. Choudry; Z. H. Iqbal; M. Ansarie; N. Ahmad

doi:10.5588/ijtld.16.0444

Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

A. Javaid, R. Hasan, A. Zafar, M. A. Chaudry, S. Qayyum, E. Qadeer, Z. Shaheen, N. Agha, N. Rizvi, M. Z. Afridi, M. K. Chima, A. R. Khan, A. Ghafoor, S. Khan, S. R. Awan, S. Akhtar, K. Choudry, Z. H. Iqbal, M. Ansarie, N. Ahmad

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	21
Issue number	3
DOIs	https://doi.org/10.5588/ijtld.16.0444
Publication status	Published - 1 Mar 2017

Keywords

Drug resistance
Pakistan
Retreatment cases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.16.0444

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Javaid, A., Hasan, R., Zafar, A., Chaudry, M. A., Qayyum, S., Qadeer, E., Shaheen, Z., Agha, N., Rizvi, N., Afridi, M. Z., Chima, M. K., Khan, A. R., Ghafoor, A., Khan, S., Awan, S. R., Akhtar, S., Choudry, K., Iqbal, Z. H., Ansarie, M., & Ahmad, N. (2017). Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan. International Journal of Tuberculosis and Lung Disease, 21(3), 303-308. https://doi.org/10.5588/ijtld.16.0444

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title = "Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan",

abstract = "BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.",

keywords = "Drug resistance, Pakistan, Retreatment cases",

author = "A. Javaid and R. Hasan and A. Zafar and Chaudry, {M. A.} and S. Qayyum and E. Qadeer and Z. Shaheen and N. Agha and N. Rizvi and Afridi, {M. Z.} and Chima, {M. K.} and Khan, {A. R.} and A. Ghafoor and S. Khan and Awan, {S. R.} and S. Akhtar and K. Choudry and Iqbal, {Z. H.} and M. Ansarie and N. Ahmad",

note = "Publisher Copyright: {\textcopyright} 2017 The Union.",

year = "2017",

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doi = "10.5588/ijtld.16.0444",

language = "English",

volume = "21",

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Javaid, A, Hasan, R , Zafar, A, Chaudry, MA, Qayyum, S, Qadeer, E, Shaheen, Z, Agha, N, Rizvi, N, Afridi, MZ, Chima, MK, Khan, AR, Ghafoor, A, Khan, S, Awan, SR, Akhtar, S, Choudry, K, Iqbal, ZH, Ansarie, M & Ahmad, N 2017, 'Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 3, pp. 303-308. https://doi.org/10.5588/ijtld.16.0444

TY - JOUR

T1 - Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

AU - Javaid, A.

AU - Hasan, R.

AU - Zafar, A.

AU - Chaudry, M. A.

AU - Qayyum, S.

AU - Qadeer, E.

AU - Shaheen, Z.

AU - Agha, N.

AU - Rizvi, N.

AU - Afridi, M. Z.

AU - Chima, M. K.

AU - Khan, A. R.

AU - Ghafoor, A.

AU - Khan, S.

AU - Awan, S. R.

AU - Akhtar, S.

AU - Choudry, K.

AU - Iqbal, Z. H.

AU - Ansarie, M.

AU - Ahmad, N.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

AB - BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

KW - Drug resistance

KW - Pakistan

KW - Retreatment cases

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U2 - 10.5588/ijtld.16.0444

DO - 10.5588/ijtld.16.0444

M3 - Article

C2 - 28225340

AN - SCOPUS:85015146454

SN - 1027-3719

VL - 21

SP - 303

EP - 308

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 3

ER -

Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

Abstract

Keywords

UN SDGs

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