Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

A. Javaid; R. Hasan; A. Zafar; M. A. Chaudry; S. Qayyum; E. Qadeer; Z. Shaheen; N. Agha; N. Rizvi; M. Z. Afridi; M. K. Chima; A. R. Khan; A. Ghafoor; S. Khan; S. R. Awan; S. Akhtar; K. Choudry; Z. H. Iqbal; M. Ansarie; N. Ahmad

doi:10.5588/ijtld.16.0444

Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

A. Javaid
, R. Hasan
, A. Zafar
, M. A. Chaudry
, S. Qayyum
, E. Qadeer
, Z. Shaheen
, N. Agha
, N. Rizvi
, M. Z. Afridi
, M. K. Chima
, A. R. Khan
, A. Ghafoor
, S. Khan
, S. R. Awan
, S. Akhtar
, K. Choudry
, Z. H. Iqbal
, M. Ansarie
, N. Ahmad

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

Original language	English (UK)
Pages (from-to)	303-308
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	21
Issue number	3
DOIs	https://doi.org/10.5588/ijtld.16.0444
Publication status	Published - 1 Mar 2017

Keywords

Drug resistance
Pakistan
Retreatment cases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.16.0444

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Javaid, A., Hasan, R., Zafar, A., Chaudry, M. A., Qayyum, S., Qadeer, E., Shaheen, Z., Agha, N., Rizvi, N., Afridi, M. Z., Chima, M. K., Khan, A. R., Ghafoor, A., Khan, S., Awan, S. R., Akhtar, S., Choudry, K., Iqbal, Z. H., Ansarie, M., & Ahmad, N. (2017). Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan. International Journal of Tuberculosis and Lung Disease, 21(3), 303-308. https://doi.org/10.5588/ijtld.16.0444

@article{090aa1a4cfcd4548bf4c979706d4909e,

title = "Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan",

abstract = "BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1\%) were susceptible to all first-line drugs, 255 (46.9\%) were resistant to at least one anti-tuberculosis drug and 132 (24.3\%) were MDR-TB. Among MDRTB isolates, 47.0\% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4\%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.",

keywords = "Drug resistance, Pakistan, Retreatment cases",

author = "A. Javaid and R. Hasan and A. Zafar and Chaudry, \{M. A.\} and S. Qayyum and E. Qadeer and Z. Shaheen and N. Agha and N. Rizvi and Afridi, \{M. Z.\} and Chima, \{M. K.\} and Khan, \{A. R.\} and A. Ghafoor and S. Khan and Awan, \{S. R.\} and S. Akhtar and K. Choudry and Iqbal, \{Z. H.\} and M. Ansarie and N. Ahmad",

note = "Publisher Copyright: {\textcopyright} 2017 The Union.",

year = "2017",

month = mar,

day = "1",

doi = "10.5588/ijtld.16.0444",

language = "English (UK)",

volume = "21",

pages = "303--308",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease (The Union)",

number = "3",

}

Javaid, A, Hasan, R , Zafar, A, Chaudry, MA, Qayyum, S, Qadeer, E, Shaheen, Z, Agha, N, Rizvi, N, Afridi, MZ, Chima, MK, Khan, AR, Ghafoor, A, Khan, S, Awan, SR, Akhtar, S, Choudry, K, Iqbal, ZH, Ansarie, M & Ahmad, N 2017, 'Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 3, pp. 303-308. https://doi.org/10.5588/ijtld.16.0444

TY - JOUR

T1 - Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

AU - Javaid, A.

AU - Hasan, R.

AU - Zafar, A.

AU - Chaudry, M. A.

AU - Qayyum, S.

AU - Qadeer, E.

AU - Shaheen, Z.

AU - Agha, N.

AU - Rizvi, N.

AU - Afridi, M. Z.

AU - Chima, M. K.

AU - Khan, A. R.

AU - Ghafoor, A.

AU - Khan, S.

AU - Awan, S. R.

AU - Akhtar, S.

AU - Choudry, K.

AU - Iqbal, Z. H.

AU - Ansarie, M.

AU - Ahmad, N.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

AB - BACKGROUND: Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan. OBJECTIVE : To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan. METHODS : To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country. RESULT S : Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDRTB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates. CONCLUS ION: Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.

KW - Drug resistance

KW - Pakistan

KW - Retreatment cases

UR - https://www.scopus.com/pages/publications/85015146454

U2 - 10.5588/ijtld.16.0444

DO - 10.5588/ijtld.16.0444

M3 - Article

C2 - 28225340

AN - SCOPUS:85015146454

SN - 1027-3719

VL - 21

SP - 303

EP - 308

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 3

ER -

Pattern of first-and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan

Abstract

Keywords

UN SDGs

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